Lipid metabolism in health and disease

健康和疾病中的脂质代谢

• 批准号: nhmrc : 1077703
• 负责人: Prof Matthew Watt
• 金额: $ 42.58万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Research Fellowships
• 财政年份: 2015
• 资助国家: 澳大利亚
• 起止时间: 2015-01-01 至 2019-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/lipid-metabolism-health-disease/518528
• 关键词: Lipid; metabolism; health; disease

Obesity is associated with type 2 diabetes, fatty liver disease, cardiovascular disease and cancer. These inter-related diseases reduce life expectancy and their treatments come at an enormous financial cost. The overriding aim of this work is to understand the molecular and cellular regulation of lipid metabolism in skeletal muscle, liver and adipose tissue, and how this impacts endocrine function to affect the pathogenesis of types 2 diabetes and prostate cancer.

肥胖与2型糖尿病、脂肪肝、心血管疾病和癌症有关。这些相互关联的疾病降低了预期寿命，其治疗需要巨大的经济成本。这项工作的首要目标是了解骨骼肌，肝脏和脂肪组织中脂质代谢的分子和细胞调节，以及这如何影响内分泌功能，从而影响2型糖尿病和前列腺癌的发病机制。