Deciphering new regulators of lipid metabolism: a focus on lipid droplets

破译脂质代谢的新调节因子：关注脂滴

• 批准号: DP210102358
• 负责人: Prof Matthew Watt
• 金额: $ 47.8万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2021
• 资助国家: 澳大利亚
• 起止时间: 2021-01-01 至 2023-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP210102358
• 关键词: Deciphering; new; regulators; lipid; metabolism

Lipid droplets store lipids in cells and the mitochondria break down this lipid to generate energy. Both organelles are critical for energy metabolism and cell survival. This project aims to determine the proteins that regulate the interaction between mitochondria and lipid droplets, and how these proteins regulate metabolism. It is anticipated that this project will identify the essential components of lipid droplet-mitochondria interactions and their impact on regulating cellular lipid metabolism. The intended outcome of this project is to provide fundamental new knowledge in understanding how organelles interact and how lipid metabolism is regulated. This knowledge has applications for the primary industries and biotechnology sector.

脂滴将脂质储存在细胞中，线粒体分解这些脂质以产生能量。这两种细胞器对能量代谢和细胞存活都至关重要。该项目旨在确定调节线粒体和脂滴之间相互作用的蛋白质，以及这些蛋白质如何调节代谢。预计本项目将确定脂滴-线粒体相互作用的基本成分及其对调节细胞脂质代谢的影响。该项目的预期结果是为理解细胞器如何相互作用和脂质代谢如何调节提供基本的新知识。这些知识在初级产业和生物技术领域都有应用。