Altered protein secretion links the fatty liver to metabolic disease

蛋白质分泌改变将脂肪肝与代谢疾病联系起来

• 批准号: nhmrc : 1061278
• 负责人: Prof Matthew Watt
• 金额: $ 27.73万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2014
• 资助国家: 澳大利亚
• 起止时间: 2014-01-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/altered-protein-secretion-metabolic-disease/454876
• 关键词: Altered; protein; secretion; links; fatty

The liver secretes proteins to alter metabolism in other tissues of the body. Fatty liver is a major feature of obesity and type 2 diabetes. This project aims to understand how fatty liver changes protein secretion and how this impacts on metabolic processes. The outcomes of this project will be the identification of protein biomarkers of fatty liver and the prediction of insulin resistance development in other tissues of the body.

肝脏分泌蛋白质来改变身体其他组织的新陈代谢。脂肪肝是肥胖和2型糖尿病的主要特征。这个项目旨在了解脂肪肝是如何改变蛋白质分泌的，以及这是如何影响代谢过程的。该项目的成果将是识别脂肪肝的蛋白质生物标记物，并预测身体其他组织中胰岛素抵抗的发展。