Identifying a novel role for pigment epithelium-derived factor in obesity-related metabolic dysfunction

确定色素上皮衍生因子在肥胖相关代谢功能障碍中的新作用

• 批准号: nhmrc : 606561
• 负责人: Prof Matthew Watt
• 金额: $ 24.11万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2010
• 资助国家: 澳大利亚
• 起止时间: 2010-01-01 至 2012-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/identifying-novel-role-metabolic-dysfunction/82410
• 关键词: Identifying; novel; role; pigment; epithelium

Obesity is an important factor contributing to insulin resistance and type 2 diabetes; however, the factors linking these disorders are not well defined. A protein called PEDF is elevated in obesity and type 2 diabetes. This project will examine how PEDF causes insulin resistance and whether blocking PEDF's actions prevents insulin resistance. Successful completion of this project may lead to therapeutics that reduce the risk of developing type 2 diabetes.

肥胖是导致胰岛素抵抗和2型糖尿病的重要因素;然而，与这些疾病相关的因素尚未明确。一种称为PEDF的蛋白质在肥胖和2型糖尿病中升高。本项目将研究PEDF如何导致胰岛素抵抗，以及阻断PEDF的作用是否可以预防胰岛素抵抗。该项目的成功完成可能会导致治疗，降低发展2型糖尿病的风险。