AUDITORY EVOKED BRAIN POTENTIALS IN NEUROLOGICAL DISEASE

神经系统疾病中听觉诱发的大脑电位

• 批准号: 3394645
• 负责人: Arnold Starr
• 金额: $ 47.42万
• 依托单位: UNIVERSITY OF CALIFORNIA-IRVINE
• 依托单位国家: 美国
• 财政年份: 1977
• 资助国家: 美国
• 起止时间: 1977-09-01 至 1991-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3394645
• 关键词: aphasia; auditory cortex; auditory discrimination; auditory feedback; auditory pathways; auditory stimulus; axon; binaural hearing; cognition disorders; hearing tests; neural information processing; neuropsychological tests; psychoacoustics; semantics; short term memory; sonar; stimulus /response

We plan to study auditory evoked potentials (AEPs) in both clinical neurological disorders and animal experiments to define neural mechanisms of the generation of these potentials and their application to disordered brain function. In particular, we will study in experimental animals the role of cells and nerve fibers in generating far-field auditory brainstem components using specific lesion methods and in an in-vitro model system using nerve fibers passing between fluid compartments of different volumes and impedances. Long-latency AEPs related to the encoding of words and tones and their subsequent memorization will be studied in normal subjects and patients with focal hemispheric lesions to define neural correlates of language processing and auditory memory. The definition of binaural processes relevant for sound localization will be defined in middle and long-latency AEPs by the occurence of binaural interaction components and related to several psychoacoustic measures in normal subjects, patients with neurological lesions, and in children during maturation.

我们计划研究两者的听觉诱发电位（AEPs）