AUDITORY EVOKED BRAIN POTENTIALS IN NEUROLOGICAL DISEASE

神经系统疾病中听觉诱发的大脑电位

• 批准号: 3394647
• 负责人: Arnold Starr
• 金额: $ 35.11万
• 依托单位: UNIVERSITY OF CALIFORNIA-IRVINE
• 依托单位国家: 美国
• 财政年份: 1977
• 资助国家: 美国
• 起止时间: 1977-09-01 至 1987-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3394647
• 关键词: aphasia; auditory cortex; auditory discrimination; auditory feedback; auditory pathways; auditory stimulus; brain disorder diagnosis; brain disorders; brain electrical activity; brain stem; cognition disorders; coma; electrophysiology; evoked potentials; experimental brain lesion; hearing tests; hippocampus; human subject; language disorders; medial geniculate body; neural information processing; neurophysiology; neuropsychological tests; stimulus /response; thalamic nuclei

We plan to study auditory evoked potentials in both clinical neurological disorders and animal experiments to define neural mechanisms of the generation of these potentials. In particular, we will study in experimental animals the role of pontine auditory structures in generating auditory brainstem components using discrete lesion methods. The generation of middle-latency, long-latency, and endogenous components will be examined using electrical recording and lesion methods in monkeys engaged in an auditory discrimination task. The application of auditory evoked potentials to patients with neurological disorders will be for 1) longlatency and endogenous components during the recovery from coma; 2) the effects of task complexity on endogenous components in dementing illnesses and 3) endogenous components during the catagorization of words in patients with aphasia.

我们计划研究听觉诱发电位在临床神经 疾病和动物实验，以确定神经机制的 这些潜力的产生。 特别是，我们将研究在 实验动物脑桥听觉结构的作用， 听觉脑干成分的离散损伤方法。 的 中潜伏期、长潜伏期和内源性成分的产生将 在猴子中使用电记录和损伤方法进行检查 进行听觉辨别任务。 听觉的应用 神经系统疾病患者的诱发电位将用于1） 长潜伏期和内源性成分; 2） 任务复杂性对痴呆症内源性成分的影响 3）患者词的分类过程中的内源性成分 失语症