EFFECTS OF ETHANOL TREATMENT ON PHENYTOIN METABOLISM IN RATS

乙醇治疗对大鼠苯妥英代谢的影响

• 批准号: 4687723
• 负责人: E A LANE
• 金额: --
• 依托单位: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/4687723
• 关键词: alcoholic beverage consumption; anticonvulsants; blood chemistry; drug metabolism; ethanol; hydroxylation; liver metabolism; microsomes; phenytoin; tissue /cell culture; toxin metabolism

Phenytoin is a drug that exhibits undesirable side effects at concentrations just above those producing the desired anticonvulsant effect. Therefore, understanding the mechanism by which phenytoin blood concentrations are affected by alcohol consumption should improve therapy with this drug. Towards this goal the preparation of rat liver microsomal fractions and some standard methods for evaluation of drug metabolism have been established.

苯妥英是一种药物，表现出不良的副作用， 浓度刚好高于产生所需抗惊厥药的浓度 效果 因此，了解苯妥英血液中 浓度受酒精消费的影响应改善治疗 用这种药。 为实现这一目标，制备大鼠肝微粒体 馏分和一些标准的药物代谢评价方法， 确立了习