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EFFECTS OF ETHANOL TREATMENT ON PHENYTOIN METABOLISM IN RATS

EFFECTS OF ETHANOL TREATMENT ON PHENYTOIN METABOLISM IN RATS
乙醇治疗对大鼠苯妥英代谢的影响
批准号：
4687723
负责人：
E A LANE
金额：
$0.0万
依托单位：
NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/4687723
关键词：
alcoholic beverage consumption anticonvulsants blood chemistry drug metabolism ethanol hydroxylation liver metabolism microsomes phenytoin tissue /cell culture toxin metabolism

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中文摘要
翻译
苯妥英是一种在治疗中表现出不良副作用的药物 浓度略高于产生所需抗惊厥剂的浓度 效果。因此，了解苯妥英血液的作用机制 酒精浓度受饮酒影响应改善治疗 用这种药。为实现这一目标，制备了大鼠肝微粒体 分级和一些评价药物代谢的标准方法有 已经建立了。
英文摘要
Phenytoin is a drug that exhibits undesirable side effects at concentrations just above those producing the desired anticonvulsant effect. Therefore, understanding the mechanism by which phenytoin blood concentrations are affected by alcohol consumption should improve therapy with this drug. Towards this goal the preparation of rat liver microsomal fractions and some standard methods for evaluation of drug metabolism have been established.
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