ACETYLATION PHENOTYPE OF ALCOHOLICS

酒精的乙酰化表型

• 批准号: 3817399
• 负责人: E A LANE
• 金额: --
• 依托单位: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3817399
• 关键词: acetylation; alcoholism /alcohol abuse; blood chemistry; drug metabolism; gene expression; high performance liquid chromatography; human subject; metabolism disorder; pharmacokinetics; sulfanilamides; urinalysis

Any coincidence of the slow acetylator phenotype and alcoholism will be investigated in this study. The proportion of alcoholic subjects that exhibits the slow acetylator phenotype has been compared with the proportion of normal volunteers that exhibits the slow acetylator phenotype. The acetylator phenotype has been measured in normal volunteers and recovered alcoholics, who are not related to each other. The recovered alcoholics have a history of alcoholism and the normal volunteers are nonalcoholic and have no first degree relatives who are alcoholic. The acetylator phenotype was determined after a single dose of sulfamethazine by measurement of blood and urine concentrations of sulfamethazine and its acetylated metabolite. These were quantified by high pressure liquid chromatography. The acetylator phenotype has been determined in a total of 37 alcoholics and 26 unrelated normal volunteers. Both groups contained 54% fast acetylators (20/37 and 14/26). Power analysis indicates that 2430 subjects would be required for these proportions to represent a statistically significant difference.

慢乙酰化表型和酗酒的任何巧合 将在本研究中进行调查。 酗酒者中表现出缓慢的 乙酰化表型已与乙酰化表型的比例进行了比较 表现出慢乙酰化表型的正常志愿者。 乙酰化表型已在正常志愿者中测量， 康复的酗酒者，他们彼此没有关系。 的 康复的酗酒者有酗酒史， 志愿者不酗酒，没有一级亲属， 都是酒鬼 乙酰化表型在单次给药后测定。 磺胺二甲嘧啶血、尿浓度测定法 磺胺二甲嘧啶及其乙酰化代谢物。 这些是 通过高压液相色谱法定量。 乙酰化表型已确定在总共37个 26名无血缘关系的正常志愿者。 两组 含有54%的快速乙酰化剂（20/37和14/26）。 功率分析 表明需要2430名受试者 比例代表统计学显著差异。