ACETYLATION PHENOTYPE OF ALCOHOLICS

慢乙酰化表型和酒精中毒的任何重合 将在这项研究中进行调查。 酗酒受试者表现出迟缓的比例 乙酰化产物的表型与 表现出慢乙酰化表型的正常志愿者。 已测量了正常志愿者和健康志愿者的乙酰化表型 康复的酗酒者，他们彼此没有血缘关系。这个 康复的酗酒者有酗酒史，正常 志愿者不酗酒，也没有一级亲属 都是酒鬼。 单次给药后测定乙酰化产物表型 磺胺二甲嘧啶血药浓度和尿药浓度测定 磺胺二甲嘧啶及其乙酰化代谢物。这些都是 用高压液相色谱定量。 共有37例患者被确定了乙酰化表型。 酗酒者和26名无血缘关系的正常志愿者。两组均为 快速乙酰化者占54%(20/37和14/26)。功率分析 表明这些将需要2430名受试者 比例代表统计学上的显著差异。

Any coincidence of the slow acetylator phenotype and alcoholism will be investigated in this study. The proportion of alcoholic subjects that exhibits the slow acetylator phenotype has been compared with the proportion of normal volunteers that exhibits the slow acetylator phenotype. The acetylator phenotype has been measured in normal volunteers and recovered alcoholics, who are not related to each other. The recovered alcoholics have a history of alcoholism and the normal volunteers are nonalcoholic and have no first degree relatives who are alcoholic. The acetylator phenotype was determined after a single dose of sulfamethazine by measurement of blood and urine concentrations of sulfamethazine and its acetylated metabolite. These were quantified by high pressure liquid chromatography. The acetylator phenotype has been determined in a total of 37 alcoholics and 26 unrelated normal volunteers. Both groups contained 54% fast acetylators (20/37 and 14/26). Power analysis indicates that 2430 subjects would be required for these proportions to represent a statistically significant difference.