ACETYLATION PHENOTYPE OF ALCOHOLICS

慢乙酰化表型和酗酒的任何巧合都将是 在这项研究中调查。 酗酒者中表现出缓慢乙酰化的比例 将表型与正常志愿者的比例进行比较， 表现出慢乙酰化表型。 将在正常志愿者中测量乙酰化表型， 康复的酗酒者，他们彼此没有关系。 回收的 酗酒者应该有酗酒史，而正常的志愿者 不酗酒，没有一级亲属酗酒。 乙酰化因子表型将在单次给药后确定。 磺胺二甲嘧啶血、尿浓度测定法 磺胺甲基嘧啶及其乙酰化代谢物。 这些将通过以下方式进行衡量： 高压液相色谱法 乙酰化表型已经确定了共38个酗酒者 和28名无关的正常志愿者。 这个数字的主题是 不足以得出任何结论的相对分布， 慢乙酰化表型。

Any coincidence of the slow acetylator phenotype and alcoholism will be investigated in this study. The proportion of alcoholic subjects that exhibits the slow acetylator phenotype is to be compared with the proportion of normal volunteers that exhibits the slow acetylator phenotype. The acetylator phenotype will be measured in normal volunteers and recovered alcoholics, who are not related to each other. The recovered alcoholics should have a history of alcoholism and the normal volunteers should be nonalcoholic and have no first degree relative who is alcoholic. The acetylator phenotype will be determined after a single dose of sulfamethazine by measurement of blood and urine concentrations of sulfamethanzine and its acetylated metabolite. These will be measured by high pressre liquid chromatography. The acetylator phenotype has been determined for a total of 38 alcoholics and 28 unrelated normal volunteers. This number of subjects is insufficient to draw any conclusions regarding the relative distribution of the slow acetylator phenotype.