ACETYLATION PHENOTYPE OF ALCOHOLICS

缓慢乙酰化表型和酗酒的任何巧合都将是 本研究中进行了调查。 表现出缓慢乙酰化的酗酒受试者的比例 表型将与正常志愿者的比例进行比较 表现出缓慢的乙酰化表型。 将在正常志愿者中测量乙酰化表型 康复的酗酒者，彼此之间没有亲属关系。 康复者 酗酒者应有酗酒史，正常志愿者 应该不酗酒，并且没有酗酒的一级亲属。 乙酰化表型将在单剂量后确定 通过测量血液和尿液中磺胺二甲嗪的浓度 磺胺甲嗪及其乙酰化代谢物。 这些将通过以下方式衡量 高压液相色谱法。 总共 38 名酗酒者的乙酰化表型已被确定 以及28名无关的正常志愿者。 这个科目数是 不足以得出有关相对分布的任何结论 慢乙酰化表型。

Any coincidence of the slow acetylator phenotype and alcoholism will be investigated in this study. The proportion of alcoholic subjects that exhibits the slow acetylator phenotype is to be compared with the proportion of normal volunteers that exhibits the slow acetylator phenotype. The acetylator phenotype will be measured in normal volunteers and recovered alcoholics, who are not related to each other. The recovered alcoholics should have a history of alcoholism and the normal volunteers should be nonalcoholic and have no first degree relative who is alcoholic. The acetylator phenotype will be determined after a single dose of sulfamethazine by measurement of blood and urine concentrations of sulfamethanzine and its acetylated metabolite. These will be measured by high pressre liquid chromatography. The acetylator phenotype has been determined for a total of 38 alcoholics and 28 unrelated normal volunteers. This number of subjects is insufficient to draw any conclusions regarding the relative distribution of the slow acetylator phenotype.