ACETYLATION PHENOTYPE OF ALCOHOLICS

慢乙酰化表型和酒精中毒的任何重合 在本研究中进行了调查。 酒精受试者中表现出慢乙酰化的比例 表型将与正常志愿者的比例进行比较 表现出缓慢的乙酰化表型。 乙酰化器的表型将在正常志愿者和 康复的酗酒者，他们彼此没有血缘关系。找回的人 酗酒者应该有酗酒史，而正常的志愿者 应为非酗酒者，且没有酗酒者的一级亲属。 乙酰化器表型将在单次剂量的 磺胺二甲嘧啶血药浓度和尿药浓度测定 磺胺甲肼及其乙酰化代谢物。这些将通过以下方式衡量 高压液相色谱仪。 共有38名酗酒者的乙酰化表型被确定。 和28名无血缘关系的正常志愿者。受试者的数量是 不足以得出任何关于 慢乙酰化表型。

Any coincidence of the slow acetylator phenotype and alcoholism will be investigated in this study. The proportion of alcoholic subjects that exhibits the slow acetylator phenotype is to be compared with the proportion of normal volunteers that exhibits the slow acetylator phenotype. The acetylator phenotype will be measured in normal volunteers and recovered alcoholics, who are not related to each other. The recovered alcoholics should have a history of alcoholism and the normal volunteers should be nonalcoholic and have no first degree relative who is alcoholic. The acetylator phenotype will be determined after a single dose of sulfamethazine by measurement of blood and urine concentrations of sulfamethanzine and its acetylated metabolite. These will be measured by high pressre liquid chromatography. The acetylator phenotype has been determined for a total of 38 alcoholics and 28 unrelated normal volunteers. This number of subjects is insufficient to draw any conclusions regarding the relative distribution of the slow acetylator phenotype.