APPLICATION OF PHARMACOKINETICS TO NEUROTRANSMITTER DISPOSITION

药代动力学在神经递质分布中的应用

• 批准号: 3822978
• 负责人: E A LANE
• 金额: --
• 依托单位: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3822978
• 关键词: 3 methoxy 4 hydroxyphenylethyleneglycol; antidepressants; cerebrospinal fluid; desipramine; drug metabolism; gas chromatography mass spectrometry; human subject; liver cirrhosis; liver metabolism; melatonin; neurotransmitter metabolism; norepinephrine

A model for the disposition of centrally and peripherally produced norepinephrine has been used to design experiments to separately quantify the central and peripheral production rates of norepinephrine in vivo. Analytical methods required for the execution of these studies have been established in this laboratory. These include the measurement of norepinephrine, normetanephrine, 3-methoxy-4-hydroxy phenylglycol and vanilmandelic acid by gas chromatography-mass spectrometry.

一个处理集中和周边生产的 去甲肾上腺素已被用于设计实验， 体内去甲肾上腺素的中枢和外周产生率。 执行这些研究所需的分析方法已 建立在这个实验室里。 其中包括测量 去甲肾上腺素、去甲甲肾上腺素、3-甲氧基-4-羟基苯乙二醇和 通过气相色谱-质谱法测定香草扁桃酸。