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APPLICATION OF PHARMACOKINETICS TO NEUROTRANSMITTER DISPOSITION

APPLICATION OF PHARMACOKINETICS TO NEUROTRANSMITTER DISPOSITION
药代动力学在神经递质分布中的应用
批准号：
3822978
负责人：
E A LANE
金额：
$0.0万
依托单位：
NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/3822978
关键词：
3 methoxy 4 hydroxyphenylethyleneglycol antidepressants cerebrospinal fluid desipramine drug metabolism gas chromatography mass spectrometry human subject liver cirrhosis liver metabolism melatonin neurotransmitter metabolism norepinephrine

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中文摘要
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英文摘要
A model for the disposition of centrally and peripherally produced norepinephrine has been used to design experiments to separately quantify the central and peripheral production rates of norepinephrine in vivo. Analytical methods required for the execution of these studies have been established in this laboratory. These include the measurement of norepinephrine, normetanephrine, 3-methoxy-4-hydroxy phenylglycol and vanilmandelic acid by gas chromatography-mass spectrometry.
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APPLICATION OF PHARMACOKINETICS TO NEUROTRANSMITTER DISPOSITION
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