APPLICATION OF PHARMACOKINETICS TO NEUROTRANSMITTER DISPOSITION

一种集中生产和外围生产的配置模型 去甲肾上腺素已经被用来设计实验，以分开 量化中心和外围的生产率 体内的去甲肾上腺素。所需的分析方法 这些研究的执行已经建立在这个 实验室。这些包括去甲肾上腺素的测量， 去甲肾上腺素、3-甲氧基-4-羟基苯甘醇和 气相色谱-质谱法测定香草扁桃酸。 在动物身上的初步实验表明，一些 必须进一步改进分析方法，以便 为我们的实验设计服务。

A model for the disposition of centrally and peripherally produced norepinephrine has been used to design experiments to separately quantify the central and peripheral production rates of norepinephrine in vivo. Analytical methods required for the execution of these studies have been established in this laboratory. These include the measurement of norepinephrine, normetanephrine, 3-methoxy-4-hydroxy phenylglycol and vanilmandelic acid by gas chromatographymass spectrometry. Preliminary experiments in animals have demonstrated that some of the analytical methods must be further refined in order to serve our experimental design.