APPLICATION OF PHARMACOKINETICS TO NEUROTRANSMITTER DISPOSITION

药代动力学在神经递质分布中的应用

• 批准号: 3821252
• 负责人: E A LANE
• 金额: --
• 依托单位: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3821252
• 关键词: 3 methoxy 4 hydroxyphenylethyleneglycol; antidepressants; cerebrospinal fluid; drug metabolism; gas chromatography mass spectrometry; human subject; neurotransmitter metabolism; norepinephrine; normetanephrine

A model for the disposition of centrally and peripherally produced norepinephrine has been used to design experiments to separately quantify the central and peripheral production rates of norepinephrine in vivo. Analytical methods required for the execution of these studies have been established in this laboratory. These include the measurement of norepinephrine, normetanephrine, 3-methoxy-4-hydroxy phenylglycol and vanilmandelic acid by gas chromatographymass spectrometry. Preliminary experiments in animals have demonstrated that some of the analytical methods must be further refined in order to serve our experimental design.

一个处理集中和周边生产的 去甲肾上腺素被用来设计实验， 量化中央和外围生产率 体内去甲肾上腺素 所需的分析方法 这些研究的执行已在本 实验室 这些包括去甲肾上腺素的测量， 去甲间烷醇、3-甲氧基-4-羟基苯基乙二醇和 香草扁桃酸的气相色谱-质谱联用 初步的动物实验表明， 分析方法必须进一步完善， 服务于我们的实验设计