课题基金 / 基金详情

APPLICATION OF PHARMACOKINETICS TO NEUROTRANSMITTER DISPOSITION

APPLICATION OF PHARMACOKINETICS TO NEUROTRANSMITTER DISPOSITION
药代动力学在神经递质分布中的应用
批准号：
3821252
负责人：
E A LANE
金额：
$0.0万
依托单位：
NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/3821252
关键词：
3 methoxy 4 hydroxyphenylethyleneglycol antidepressants cerebrospinal fluid drug metabolism gas chromatography mass spectrometry human subject neurotransmitter metabolism norepinephrine normetanephrine

项目摘要

项目成果

E A LANE的其他基金

相似基金

相关文献

中文摘要
翻译
点击翻译按钮获取中文摘要
英文摘要
A model for the disposition of centrally and peripherally produced norepinephrine has been used to design experiments to separately quantify the central and peripheral production rates of norepinephrine in vivo. Analytical methods required for the execution of these studies have been established in this laboratory. These include the measurement of norepinephrine, normetanephrine, 3-methoxy-4-hydroxy phenylglycol and vanilmandelic acid by gas chromatographymass spectrometry. Preliminary experiments in animals have demonstrated that some of the analytical methods must be further refined in order to serve our experimental design.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
EVALUATION OF DRUG METABOLIZING STATUS BY CARBON DIOXIDE BREATH TESTS
ACETYLATION PHENOTYPE OF ALCOHOLICS
EVALUATION OF DRUG METABOLIZING STATUS BY CARBON DIOXIDE BREATH TESTS
APPLICATION OF PHARMACOKINETICS TO NEUROTRANSMITTER DISPOSITION
海外基金