ACETYLATION PHENOTYPE OF ALCOHOLICS

酒精的乙酰化表型

• 批准号: 3821245
• 负责人: E A LANE
• 金额: --
• 依托单位: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3821245
• 关键词: acetylation; alcoholism /alcohol abuse; antibiotics; blood chemistry; drug metabolism; gene expression; high performance liquid chromatography; human subject; metabolism disorder; pharmacokinetics; urinalysis

Any coincidence of the slow acetylator phenotype and alcoholism will be investigated in this study. The proportion of alcoholic subjects that exhibits the slow acetylator phenotype is to be compared with the proportion of normal volunteers that exhibits the slow acetylator phenotype. The acetylator phenotype will be measured in normal volunteers and recovered alcoholics, who are not related to each other. The recovered alcoholics should have a history of alcoholism and the normal volunteers should be nonalcoholic and have no first degree relatives who are alcoholic. The acetylator phenotype will be determined after a single dose of sulfamethazine by measurement of blood and urine concentrations of sulfamethazine and its acetylated metabolite. These will be quantified by high pressure liquid chromatography. The acetylator phenotype has been determined in a total of 38 alcoholics and 28 unrelated normal volunteers. This number of subjects is insufficient to draw any conclusions regarding the relative distribution on the slow acetylator phenotype in the two populations.

慢乙酰化表型和酗酒的任何巧合 将在本研究中进行调查。 酗酒者中表现出缓慢的 乙酰化表型与以下比例进行比较： 表现出慢乙酰化表型的正常志愿者。 将在正常志愿者中测量乙酰化表型 和康复的酗酒者，他们彼此没有关系。 的 康复的酗酒者应该有酗酒史， 正常的志愿者应该是非酒精性的，没有一级学位 酗酒的亲戚。 单次给药后将确定乙酰化表型 通过测量血液和尿液中的磺胺二甲嘧啶 磺胺二甲嘧啶及其乙酰化代谢物的浓度。 这些将通过高压液相色谱法进行定量。 乙酰化表型已确定在总共38个 28名无血缘关系的正常志愿者。 此数目的 不足以得出任何结论， 慢乙酰化表型的相对分布 人口。