FACTORS DETERMINING MAXIMAL EXERCISE PERFORMANCE IN MAN

决定人类最大运动表现的因素

• 批准号: 3813645
• 负责人: J L FLEG
• 金额: --
• 依托单位: NATIONAL INSTITUTE ON AGING
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3813645
• 关键词: aging; body physical activity; cardiac output; cardiovascular stress test; clinical chemistry; electrocardiography; exercise; gender difference; heart disorder diagnosis; heart imaging /visualization /scanning; human middle age (35-64); human old age (65+); intracardiac volume; oxygen consumption; peripheral nervous system; pulmonary respiration; radionuclide diagnosis

We have recently demonstrated in 184 non endurance trained non obese men and women from the Baltimore Longitudinal Study of Aging (BLSA) with normal maximal exercise ECGs that the age-associated decline in maximal oxygen consumption (VO.max) was markedly attenuated after VO.max was normalized for total muscle mass instead of body weight. These results suggested an important role of peripheral (vs central circulatory) factors in the age-related reduction of maximal aerobic performance. A closely related issue is whether the well documented marked increase in VO,max of older endurance trained men relative to that of age-matched peers is mediated primarily by central versus peripheral adaptations. We performed radionuclide ventriculography and VO, measurements during maximal upright bicycle ergometry in endurance trained (mean age = 65 + 5 yr, treadmill VO max = 51 + 4 ml/kg/min) and 6 age-matched sedentary (treadmill VO2max = 31 + 4 mi/kg min) men.

我们最近在 184 名未经耐力训练的非肥胖男性中进行了演示 以及来自巴尔的摩纵向衰老研究 (BLSA) 的女性 最大运动心电图显示与年龄相关的最大摄氧量下降 VO.max 标准化后，消耗量 (VO.max) 显着减弱 为总肌肉质量而不是体重。 这些结果表明 外周（相对于中枢循环）因素在 与年龄相关的最大有氧运动能力的降低。 密切相关的一个 问题是，有据可查的老年人的 VO,max 是否显着增加 受过耐力训练的男性与同龄同龄人的关系受到调节 主要是通过中枢与外周的适应。 我们表演了 放射性核素心室造影和 VO，最大直立期间的测量 耐力训练中的自行车测功（平均年龄 = 65 + 5 岁，跑步机 VO max = 51 + 4 ml/kg/min) 和 6 岁年龄匹配的久坐（跑步机 VO2max = 31 + 4 英里/公斤（分钟）) 男子。