OSTEOARTHRITIS AND AGING

骨关节炎与衰老

• 批准号: 3767799
• 负责人: J D TOBIN
• 金额: --
• 依托单位: NATIONAL INSTITUTE ON AGING
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3767799
• 关键词: aging; body composition; bone density; female; gender difference; hand; human subject; knee; longitudinal human study; osteoarthritis; radiography

Osteoarthritis (OA) is the most common rheumatic disease of the elderly. As part of the ongoing studies of OA in the Baltimore Longitudinal Study of Aging (BLSA) we have published data on radiographic hand OA in men and women, and have evaluated the association of metabolic and physiologic factors with the presence and distribution of hand and knee OA in both sexes, and with the progression of hand OA in women. In 182 women with longitudinal hand xrays, hand OA progresses more rapidly with increasing age. After age adjustment, body composition and bone mass are not independent predictors of hand OA. We developed a reliable atlas of knee OA for use in both clinical and epidemiologic studies. Using this atlas, we found that the prevalence of knee OA in 547 men and 351 women increases with age in both sexes, almost 50% of subjects aged equal to or greater than 70 have definite knee OA, and bilateral disease accounts for close to 50% of cases in both sexes aged equal to or greater than 60. In 465 men and 275 women aged equal to or greater than 40 years, after adjustment for age, obesity was significantly associated with the presence of knee OA in both sexes, while bone density was not. Serum levels of Insulin-like growth factor-I and urinary excretion of pyridinoline cross-links were inversely related to knee OA grade in 158 men and 100 women aged 19-86 years, but were no longer associated with OA after adjustment for age. In 431 men and 273 women aged equal to or greater than 40 years, after adjustment for age, we find a significant association in both sexes between hand and knee OA, supporting the concept of polyarticular OA.

骨关节炎（OA）是老年人最常见的风湿性疾病。 作为巴尔的摩纵向研究中正在进行的OA研究的一部分 我们已经发表了男性手部OA的影像学数据， 女性，并评估了代谢和生理 手和膝关节OA的存在和分布的因素， 男性和女性手OA的进展。 在182名女性中， 纵向手部X线片，随着手OA的增加， 年龄 年龄调整后，身体成分和骨量不是 手OA的独立预测因子。 我们开发了一个可靠的膝关节图谱 用于临床和流行病学研究的OA。 利用这个地图集， 我们发现，547名男性和351名女性的膝关节OA患病率增加， 随着年龄的增长，几乎50%的受试者年龄等于或大于 70多人患有明确的膝关节OA，双侧疾病占近 50%的男女病例年龄等于或大于60岁。 在465名男性中 和275名年龄等于或大于40岁的妇女，调整后， 年龄，肥胖与膝关节OA的存在显著相关， 而骨密度则没有。 血清胰岛素样 生长因子-I和尿排泄的吡啶啉交联， 在19-86岁的158名男性和100名女性中，与膝关节OA等级呈负相关 年，但在调整年龄后不再与OA相关。 在 431名男性和273名女性，年龄等于或大于40岁， 调整年龄后，我们发现男女之间存在显著关联， 手和膝关节OA之间，支持多关节OA的概念。