OSTEOARTHRITIS AND AGING

骨关节炎（OA）是老年人最常见的风湿性疾病， 估计有4000万美国人有OA的放射性证据。 作为正在进行的巴尔的摩OA纵向研究的一部分， 老龄化（BLSA），我们提出了横截面患病率， 放射学手OA和手OA的纵向进展。 我们有 我还开发了新的分级标准，扩大了凯尔格伦/劳伦斯 评分系统，验证了他们，并提出了纵向研究， 新的网络上每个单独功能的进展速度 规模 代谢和生理因素可能与 在Kellgren/Lawrence评估的BLSA子集中研究了手OA 成绩. 估计脂肪量和分布，以及肌肉和骨骼 质量和肌肉力量与OA分级相关，但这种关联是 当考虑较高OA等级的年龄分布时，不存在 for. 这些志愿者的一个子集，那些有2次或2次以上访视的志愿者， 评估这些风险因素对纵向 OA的进展。 除了年龄>60岁外， 经考克斯多因素检验，与疾病进展显著相关 比例风险模型 这项研究未能支持这一假设 生理和代谢因素与手OA有关 独立于已知的与年龄的关联。

Osteoarthritis (OA) is the most common rheumatic disease of the elderly, with 40 million Americans estimated to have radiological evidence of OA. As part of the ongoing studies of OA in the Baltimore Longitudinal Study of Aging (BLSA) we have presented the cross sectional prevalence in radiographic hand OA and the longitudinal progression of hand OA. We have also developed new grading scales that expand on the Kellgren/Lawrence scoring system, have validated them, and presented longitudinal studies on the rates of progression of each of the individual features on the new scale. The possible association of metabolic and physiologic factors with hand OA was studied in a subset of the BLSA evaluated by Kellgren/Lawrence scores. Estimates of fat mass and distribution, as well as muscle and bone mass and muscle strength were related to OA grade, but this association was not present when the age distribution of the higher OA grades was accounted for. A subset of these volunteers, those with 2 or more visits were evaluated for the effects of these risk factors on the longitudinal progression of OA. Aside from age >60 yrs none of the factors was significantly related to progression when tested by Cox multifactorial proportional hazards model. This study fails to support the hypothesis that physiologic and metabolic factors are associated with hand OA independent of their known association with age.