OSTEOARTHRITIS AND AGING

骨关节炎与衰老

• 批准号: 3802252
• 负责人: J D TOBIN
• 金额: --
• 依托单位: NATIONAL INSTITUTE ON AGING
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3802252
• 关键词: adipocytes; aging; bone density; disease /disorder proneness /risk; hand; human old age (65+); human subject; longitudinal human study; muscle cells; muscle function; osteoarthritis; tensile strength

Osteoarthritis (OA) is the most common rheumatic disease of the elderly, with 40 million Americans estimated to have radiological evidence of OA. As part of the ongoing studies of OA in the Baltimore Longitudinal Study of Aging (BLSA) we have presented the cross sectional prevalence in radiographic hand OA and the longitudinal progression of hand OA. We have also developed new grading scales that expand on the Kellgren/Lawrence scoring system, have validated them, and presented longitudinal studies on the rates of progression of each of the individual features on the new scale. The possible association of metabolic and physiologic factors with hand OA was studied in a subset of the BLSA evaluated by Kellgren/Lawrence scores. Estimates of fat mass and distribution, as well as muscle and bone mass and muscle strength were related to OA grade, but this association was not present when the age distribution of the higher OA grades was accounted for. A subset of these volunteers, those with 2 or more visits were evaluated for the effects of these risk factors on the longitudinal progression of OA. Aside from age >60 yrs none of the factors was significantly related to progression when tested by Cox multifactorial proportional hazards model. This study fails to support the hypothesis that physiologic and metabolic factors are associated with hand OA independent of their known association with age.

骨关节炎是老年人最常见的风湿性疾病， 据估计，有4000万美国人有骨性关节炎的放射证据。 作为巴尔的摩纵向研究中正在进行的OA研究的一部分 老龄化(BLSA)，我们已经提出了横断面患病率 手性骨性关节炎与手部骨性关节炎的纵向进展。我们有 我还开发了新的评级标准，在凯尔格伦/劳伦斯的基础上进行了扩展 评分系统，对它们进行了验证，并提出了关于 每个单独功能在新版本上的进度 比例。代谢和生理因素可能与 在Kellgren/Lawrence评估的BLSA的子集中对手部OA进行了研究 得分。脂肪质量和分布以及肌肉和骨骼的估计 质量和肌肉力量与骨性关节炎分级有关，但这种联系是 在计算较高的办公自动化职级的年龄分布时不存在 为。这些志愿者中有一部分是那些访问过两次或更多次的人 评估这些风险因素对纵向 骨性关节炎的进展。除了年龄和60岁以外，没有任何因素是 用COX多因素检验与进展显著相关 比例风险模型。这项研究未能支持这一假说 生理和代谢因素与手部骨性关节炎相关 与已知的与年龄的联系无关。