OSTEOARTHRITIS AND AGING

骨关节炎与衰老

• 批准号: 3745467
• 负责人: J D TOBIN
• 金额: --
• 依托单位: NATIONAL INSTITUTE ON AGING
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3745467
• 关键词: aging; body composition; bone density; female; gender difference; hand; human data; knee; longitudinal human study; male; osteoarthritis; pulmonary respiration

Osteoarthritis (OA) is the most common rheumatic disease of the elderly. As part of the ongoing studies of OA in the Baltimore Longitudinal Study of Aging (BLSA) we have evaluated the association of metabolic and physiologic factors with the presence distribution, and progression of hand and knee OA in both sexes. In 234 men and 95 women in the BLSA, aged 60 and above, definite knee OA was present in 65% of those with pain compared to 34% of those without knee pain. Prevalence of self- reported pain is significantly associated with the severity of the grade of OA in the knee.In 130 subjects with longitudinal knee xrays, we found that incidence or progression of OA occurred in 22 (17%) with grade 0-2 osteophyte changes at baseline, over a mean follow-up of 3.8q1.1 yrs; and that both age and BMI at baseline significantly predicted time to incidence or progression. In 465 men and 275 women aged 40 and above, we found that current smoking is associated with a decreased risk of osteophyte formation and knee OA in women independent of age and BMI. We found that subjects aged 40 and above with current knee pain have significantly lower aerobic capacity (AC) than those without knee pain adjusted for radiographic changes of knee OA, confirming the hypothesis that AC is diminished in persons with symptomatic knee OA. In 340 men and 208 women aged 40 and above, mean spine bone mineral density (BMD) was significantly greater in those with knee OA, after adjustment for age and BMI. There was no association between hip BMD and knee OA features. In our evaluation of familial aggregation of hand and generalized OA in the BLSA, we found clinically relevant sibling correlations for OA of the distal interphalangeal joints, after adjustment for age and gender, but no association for other hand sItes, for knee OA, or for polyarticular OA (hand and knee).

骨关节炎（OA）是老年人最常见的风湿性疾病。 作为巴尔的摩纵向研究中正在进行的OA研究的一部分 我们已经评估了代谢和衰老之间的关系， 生理因素与存在分布，和进展 两种性别的手和膝关节OA。在BLSA的234名男性和95名女性中， 年龄在60岁及以上的患者中，65%的患者存在明确的膝关节OA， 疼痛，相比之下，34%的人没有膝盖疼痛。自我控制的普遍性 报告的疼痛与疼痛等级的严重程度显著相关。 在130名接受纵向膝关节X光检查的受试者中，我们发现 22例（17%）0-2级OA发生或进展 基线时的骨赘变化，平均随访3.8q1.1年;和 基线时的年龄和BMI均能显著预测 发病率或进展。在40岁及以上的465名男性和275名女性中， 我们发现，目前的吸烟与降低 骨赘形成和膝关节骨性关节炎与年龄和BMI无关。 我们发现，40岁及以上的受试者与目前的膝盖疼痛， 有氧能力（AC）明显低于无膝关节疼痛的患者 根据膝关节OA的影像学变化进行调整，证实了假设 在有症状的膝关节OA患者中AC减少。在340人中 208名40岁及以上女性，平均脊柱骨密度 (BMD)在调整后，膝关节OA患者的 年龄和BMI。髋关节骨密度与膝关节骨性关节炎无相关性 功能.在我们的评估家庭聚集性的手， 在BLSA中，我们发现了临床相关的兄弟姐妹 调整后远端指间关节OA的相关性 与年龄和性别有关，但与其他手部部位、膝关节OA无关， 或多关节OA（手和膝关节）。