OSTEOARTHRITIS AND AGING

骨关节炎是老年人最常见的风湿性疾病， 据估计，有4000万美国人有骨性关节炎的放射证据。 作为巴尔的摩纵向研究中正在进行的OA研究的一部分 老龄化(BLSA)我们提供了男性手部骨关节炎的放射学数据，以及 已经评估了代谢和生理学之间可能的联系 影响手部骨关节炎的因素。我们现在已经评估了明确的 在BLSA的422名妇女中进行了手部骨关节炎的X线检查，并证明 随着年龄的增长，异常X线片明显增多。女性年龄低于 40岁时有1%的异常读数，从 40尺S异常率25%，延续于50尺S(77%)和60尺S(94%)； 在70岁以上的女性中，有99%的人有异常的X光片。在325名女性中 年龄40岁的人对脂肪质量和分布的估计是肯定的 与OA分级有关，而手和手臂的骨量估计为 与骨性关节炎分级呈负相关。这些联系不存在于 说明了较高骨性关节炎等级的年龄分布。同样， 血清胰岛素样生长因子-I水平与骨性关节炎呈负相关 年龄在22-86岁的115名女性的年级，但这种联系也不存在 当考虑到年龄的时候。这些研究未能支持 生理和代谢因素与手相关的假说 女性的骨性关节炎，独立于她们已知的与年龄的联系。

Osteoarthritis (OA) is the most common rheumatic disease of the elderly, with 40 million Americans estimated to have radiological evidence of OA. As part of the ongoing studies of OA in the Baltimore Longitudinal Study of Aging (BLSA) we have presented data on radiographic hand OA in men, and have evaluated the possible association of metabolic and physiologic factors with hand OA. We have now evaluated the prevalence of definite radiographic hand OA in 422 women of the BLSA, and have demonstrated that there is a marked increase in abnormal radiographs with age. Women under 40 years of age had < 1% abnormal readings which increased starting in the 40's with 25% abnormal, continuing in the 50's (77%) and 60's (94%) with > 99% of the women over 70 having abnormal radiographs. In 325 women over the age of 40 estimates of fat mass and distribution were positively related to OA grade, while estimates of bone mass of the hand and arm were negatively related to OA grade. These associations were not present when the age distribution of the higher OA grades was accounted for. Similarly, serum levels of Insulin-like growth factor-I were inversely related to OA grade in 115 women aged 22-86, but this association also was not present when age was taken into account. These studies fail to support the hypothesis that physiologic and metabolic factors are associated with hand OA in women, independent of their known association with age.