OSTEOARTHRITIS AND AGING

骨关节炎与衰老

• 批准号: 6160428
• 负责人: J D TOBIN
• 金额: --
• 依托单位: NATIONAL INSTITUTE ON AGING
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/6160428
• 关键词: African American; aging; body composition; bone imaging /visualization /scanning; caucasian American; clinical research; gender difference; genetic markers; genetic polymorphism; hand; human middle age (35-64); human old age (65+); human subject; knee; orthopedics; osteoarthritis; questionnaires; tobacco abuse

Summary of work: Osteoarthritis (OA) is the most common form of arthritis in the elderly, and is a major cause of activity limitation, physical disability and health services utilization in the elderly. As part of the ongoing studies of OA in the Baltimore Longitudinal Study of Aging (BLSA), in order to test the hypothesis that genetic markers may be implicated in the expression of OA, especially generalized (polyarticular) OA, we have examined the association between alleles of the polymorphic human aggrecan gene (at least 11 alleles identified) and bilateral hand and knee OA in 74 Caucasian men aged 60 and over. After adjustment for differences in age and obesity, we found that men who have one of the most common alleles of this aggrecan gene have a five-fold greater likelihood of having moderate to severe hand OA in multiple joints on both hands. The genetic studies have also been investigated using an epidemiological approach. We have been studying the familial association of hand OA and of generalized OA (OA in multiple hand joints plus knees) in the family members among the BLSA participants. We found that the presence of OA in each of the hand joints, in multiple hand joint sites, and generalized OA, were all more highly correlated among brothers, sisters, and in sister-brother pairs, than among unrelated people. The clinical implications of the radiographic findings of OA have been investigated by examining the association among pain reporting, personality, and radiographic knee OA, using different measures of musculo-skeletal symptoms (AIMS, NHANES-I arthritis supplement), of disability and function, and personality profiles (NEO) in the BLSA subjects, in order to further understand why some people with radiographic knee OA have pain while others do not, and why some report pain with no radiographic OA. Early results of the analysis of the AIMS data show that anxiety and depression scores are higher in men and women who report pain, but who have no x-ray evidence of OA, suggesting that anxiety and depression are risk factors for the reporting of pain in the absence of radiographic OA.

工作摘要：骨关节炎(OA)是最常见的关节炎形式 在老年人中，也是活动受限的一大原因，体力 老年人的残疾和健康服务利用情况。作为该计划的一部分 巴尔的摩老龄化纵向研究(BLSA)中正在进行的关于OA的研究， 为了验证遗传标记可能牵涉到的假设 骨性关节炎的表现，尤其是广义的(多关节)骨性关节炎，我们有 检查了多态人类的等位基因之间的关联 Aggrecan基因(已鉴定至少11个等位基因)与双侧手和 74例60岁及以上高加索男性膝关节骨性关节炎。调整后的 在年龄和肥胖方面的差异，我们发现男性拥有最多的 这种aggrecan基因的常见等位基因有五倍以上的可能性。 双手多个关节有中到重度手部骨性关节炎。 遗传学研究也通过流行病学研究进行了调查。 接近。我们一直在研究手部骨性关节炎的家族性联系 全身性骨性关节炎(多个手关节和膝盖的骨性关节炎)在家庭中的表现 BLSA参与者中的成员。我们发现骨质疏松症患者 在多个手关节位置的每个手关节，以及广义的OA， 在兄弟姐妹之间的相关性更高，在 兄弟姐妹，而不是在没有血缘关系的人中。临床部 已对骨性关节炎的放射学结果的含义进行了调查 研究疼痛报告、个性和 使用不同肌肉骨骼测量的膝关节骨关节炎X线片 残疾症状(AIMS，NHANES-I关节炎补充资料)，以及 BLSA受试者的功能和人格特征(NEO)，以便 进一步了解为什么有些膝关节骨性关节炎患者会感到疼痛 而其他人则没有，以及为什么一些人报告疼痛而没有放射学检查的骨性关节炎。 对AIMS数据的早期分析结果表明，焦虑和 报告疼痛的男性和女性的抑郁得分较高，但 没有骨性关节炎的X光证据，表明焦虑和抑郁是 在没有放射学检查的骨关节炎的情况下报告疼痛的危险因素。