BIOCHEMICAL PARAMETERS OF BONE METABOLISM--AGE AND SEX CONTRASTS

工作总结：已经证实了与年龄相关的骨量变化 无论是男性还是女性。年龄和性别相关的差异荷尔蒙， 与骨转换有关的营养和生理变量有 对阐明正常衰老和骨质疏松症的骨生理学变化有重要意义 疾病。具体来说，年龄和性别与身体变化的关系 成分，既是肥胖的标志，也是体重的衡量标准 骨上的负荷是影响骨状况和骨质疏松率的重要因素 变化。骨量变化最剧烈的速度发生在 更年期与体成分、骨量、骨标记物的变化 正在对一群围绝经期妇女进行荷尔蒙研究 被巴尔的摩老龄化纵向研究招募的人将是 每隔3个月随访一次，直到她们进入更年期。这些 研究将允许对先前发生的变化进行解释 月经停止前后及前后的变化 只有在前瞻性的纵向研究中才能体会到这一点。 初步结果比较了27名绝经前妇女(血浆 卵泡刺激素(FSH)水平均小于30IU)和世卫组织 被跟踪了至少一年，其中21名女性被归类为 围绝经期(上一次FSH后至少有一次FSH大于30 不到30人)，并在调查后被跟踪至少一年 最初FSH升高。处于绝经前的女性没有 通过DEXA扫描评估身体成分的显著变化，同时 围绝经期妇女的体量显著增加 脂肪以及他们的脂肪百分比。这些女性进入了 绝经早期也有明显的骨矿物质流失 而那些仍处于绝经前的女性 实际上仍然显著增加了骨骼中的矿物质含量 脊椎。两组髋部的骨矿物质都在流失，没有 在围绝经期组中仍可见加速这些变化 发生在月经完全停止之前，并表明 更年期的变化发生得比更年期更早 之前的想法是。

Summary of work: Age-related changes in bone mass have been demonstrated in both men and women. Age and sex related differences hormones, nutritional and physiological variables involved in bone turnover are important in elucidating changes in bone physiology in normal aging and disease. Specifically, the relationship age and sex to changes in body composition, both as a marker of obesity and as a measure of the weight bearing load on bone are important factors in bone status and rates of change. The most dramatic rates of change in bone mass occur at the menopause, and changes of body composition, bone mass, and bone markers and hormones are being investigated in a cohort of perimenopausal women recruited to the Baltimore Longitudinal Study of Aging, who will be followed at 3 month intervals as they traverse the menopause. These studies will allow for the interpretation of the changes that occur prior to and immediately around the time of the cessation of menses, changes that can only be appreciated in a prospective longitudinal study. Preliminary results compared 27 women who remained premenopausal (plasma Follicle Stimulating Hormone ( FSH ) levels all less than 30 IU) and who were followed for at least one year, with 21 women who were classified as perimenopausal ( at least one FSH greater than 30 after a previous FSH less than 30) and who were followed for at least one year after their initial elevated FSH. The women who e remained premenopausal had no significant change in body composition as assessed by DEXA scanning while the perimenopausal women had significant increases in the amount of body fat as well as their percent fat. These women who are entering the earliest stage of the menopause also had significant lose of bone mineral from their lumbar spine while those women who remained premenopausal were actually significantly still increasing the amount of bone mineral in the spine. Both groups were losing bone mineral at the hip, with no acceleration yet seen in the perimenopausal group These changes all occured prior to the complete cessation of menstruation, and indicate that changes are occuring earlier in the transition across the menopause than previously thought.