BIOCHEMICAL PARAMETERS OF BONE METABOLISM--AGE AND SEX CONTRASTS

年龄相关的骨量变化已被证明在这两个男人 和妇女 年龄和性别相关的差异激素，营养和 参与骨转换的生理变量在 阐明正常衰老和疾病中骨骼生理学的变化。 具体来说，年龄和性别与身体成分变化的关系， 既作为肥胖的标志又作为承重负荷的量度 是影响骨状态和变化率的重要因素。 的 骨量变化最剧烈的时期是绝经期， 身体成分、骨量、骨标志物和激素的变化 正在一组围绝经期妇女中进行研究， 巴尔的摩老龄化纵向研究，谁将在3 每隔一个月就会出现一次这些研究将使 对于之前和之后发生的变化的解释， 在月经停止的时候，变化只能是 在一项前瞻性纵向研究中得到赞赏。

Age related changes in bone mass have been demonstrated in both men and women. Age and sex related differences hormones, nutritional and physiological variables involved in bone turnover are important in elucidating changes in bone physiology in normal aging and disease. Specifically, the relationship age and sex to changes in body composition, both as a marker of obesity and as a measure of the weight bearing load on bone are important factors in bone status and rates of change. The most dramatic rates of change in bone mass occur at the menopause, and changes of body composition, bone mass, and bone markers and hormones are being investigated in a cohort of peri-menopausal women recruited to the Baltimore Longitudinal Study of Aging, who will be followed at 3 month intervals as they traverse the menopause. These studies will allow for the interpretation of the changes that occur prior to and immediately around the time of the cessation of menses, changes that can only be appreciated in a prospective longitudinal study.