PHYSIOLOGY OF AGING

衰老的生理学

• 批准号: 3823198
• 负责人: J D TOBIN
• 金额: --
• 依托单位: NATIONAL INSTITUTE ON AGING
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3823198
• 关键词: aging; body water; creatinine; diet; dietary proteins; human old age (65+); human subject; interview; kidney disorder; kidney function; kidney metabolism; longitudinal human study; nutrition related tag

Studies of age changes in physiologic systems have focused on the renal system of male volunteers of the Baltimore Longitudinal Study of Aging (BLSA). The possible effect of diet, specifically protein intake, on present and future kidney function (creatinine clearance) was examined. Dietary protein has an insignificant effect on simultaneous clearances or on renal function 10-18 years after the diet estimation when studied across the entire age range, and the profound effect of age is taken into account. In separate age groups, there is a small but significant positive correlation of increasing protein and increasing creatinine clearance measured at the same time, but no negative effect of higher protein intake on future clearance. In this normal population, there is no evidence to support the hypothesis that increased protein intake leads to decreased renal function. Water load tests on normal males of the BLSA demonstrated a marked defect in the ability of older subjects to excrete water. This was manifested by lower free water clearance and lower maximum urineflow in the elderly, as well as a change in time course of the response with older subjects reaching their maximum values later than the young. Studies on the glucose tolerance tests in female volunteers of the BLSA and clamp studies on athletes and volunteers from the teaching nursing home populations are reported in the Metabolism Section reports.

生理系统中年龄变化的研究集中在肾脏 巴尔的摩老龄化纵向研究的男性志愿者系统 （BLSA）。 饮食的可能影响，特别是蛋白质的摄入， 检查当前和将来的肾功能（肌酐清除率）。 膳食蛋白质对同时清除率的影响不显著， 研究饮食估计后10-18年对肾功能的影响 整个年龄范围，年龄的深刻影响被考虑在内， 帐户. 在不同的年龄组中， 蛋白质增加与肌酐清除率增加的相关性 同时测量，但没有较高的蛋白质摄入量的负面影响 未来的清除。 在这个正常人群中，没有证据表明 支持增加蛋白质摄入量导致降低 肾功能 对BLSA正常雄性动物的水负荷试验表明， 老年人排泄水分的能力。 这表现在： 老年人的自由水清除率和最大尿流率较低， 以及年龄较大的受试者的反应时间过程的变化 比年轻人晚达到最大值。 BLSA和BLA女性志愿者葡萄糖耐量试验的研究 对来自教学疗养院的运动员和志愿者的钳夹研究 人群报告见代谢章节报告。