PHYSIOLOGY OF AGING

对生理系统年龄变化的研究主要集中在肾脏。 巴尔的摩老龄化纵向研究的男性志愿者系统 (BLSA)。饮食，特别是蛋白质摄入量对 检查目前和未来的肾功能(肌酐清除量)。 饮食蛋白质对同时清除量或 饮食评估后10-18年的肾功能 整个年龄范围，以及年龄的深刻影响被考虑在内 帐号。在不同的年龄段，有一个虽小但显著的积极因素 蛋白质增加与内生肌酐清除率增加的相关性 同时测量，但不会对蛋白质摄入量过高产生负面影响 关于未来的许可。在这个正常的人群中，没有证据表明 支持蛋白质摄入量增加会导致减少的假设 肾功能。 对BLSA正常男性的水负荷测试显示出明显的缺陷 年长的受试者排泄水分的能力。这体现在以下几个方面 老年人较低的自由水清除率和较低的最大尿流量，如 以及对年龄较大的受试者反应的时间进程的变化 达到最大值的时间比年轻人晚。 BLSA和BLSA女性志愿者糖耐量试验的研究 教养院运动员和志愿者的夹具研究 新陈代谢部分的报告中报告了人口。

Studies of age changes in physiologic systems have focused on the renal system of male volunteers of the Baltimore Longitudinal Study of Aging (BLSA). The possible effect of diet, specifically protein intake, on present and future kidney function (creatinine clearance) was examined. Dietary protein has an insignificant effect on simultaneous clearances or on renal function 10-18 years after the diet estimation when studied across the entire age range, and the profound effect of age is taken into account. In separate age groups, there is a small but significant positive correlation of increasing protein and increasing creatinine clearance measured at the same time, but no negative effect of higher protein intake on future clearance. In this normal population, there is no evidence to support the hypothesis that increased protein intake leads to decreased renal function. Water load tests on normal males of the BLSA demonstrated a marked defect in the ability of older subjects to excrete water. This was manifested by lower free water clearance and lower maximum urineflow in the elderly, as well as a change in time course of the response with older subjects reaching their maximum values later than the young. Studies on the glucose tolerance tests in female volunteers of the BLSA and clamp studies on athletes and volunteers from the teaching nursing home populations are reported in the Metabolism Section reports.