TUMOR SUPPRESSOR GENES IN HUMAN HEPATOCELLULAR CARCINOMA
TUMOR SUPPRESSOR GENES IN HUMAN HEPATOCELLULAR CARCINOMA
批准号:
3752737
负责人:
E TABOR
金额:
$0.0万
依托单位国家:
美国
项目类别:
财政年份:
--
资助国家:
美国
项目状态:
未结题
起止时间:
至
关键词:
Europe adenoma gene expression gene mutation genetic polymorphism hepatoblastoma hepatocellular carcinoma human genetic material tag human tissue hyperplasia immunocytochemistry molecular cloning neoplasm /cancer genetics nucleic acid sequence polymerase chain reaction southeast Asia tumor suppressor genes
中文摘要
在肝细胞癌(HCC)中p53突变的研究
英文摘要
Studies of p53 mutations in hepatocellular carcinoma (HCC) have
continued. Results from previous studies in this laboratory in patients
from China and the U.S. were continued in patients from Europe. p53
expression was studied by immunohistochemical methods in benign and
malignant human epithelial liver lesions in 46 patients from Hungary (16
hepatocellular carcinomas, 7 hepatoblastomas, 17 focal nodular
hyperplasias, and 6 hepatocellular adenomas). Positive immunostaining
for p53 protein, indicating the probable presence of a mutation in the
p53 gene, was detected in the nuclei of tumor cells of seven of 16 HCC
patients (44%). Immunostaining of p53 was seen in one of seven
hepatoblastomas, none of 17 focal nodular hyperplasias, and none of six
hepatocellular adenomas, indicating that these other liver lesions
probably do not frequently have p53 mutations. In the liver tissue
adjacent to all the tumors studied, hepatocytes did not stain for the
presumed mutant p53 protein. The detection of mutant p53 in a relatively
high percentage of the HCC cases in Hungary, a country in which aflatoxin
contamination of the diet is rare, suggests that factors other than
aflatoxin led to p53 mutations in these patients. p53 gene mutations
appear to be uncommon in hepatoblastoma and benign liver lesions such as
focal nodular hyperplasia and hepatocellular adenoma.
Studies using single-strand conformation polymorphism (SSCP) and
sequencing are being used to identify p53 mutations in HCC patients from
Hungary, Korea, and the USA (Texas; NIH; Hawaii). In Korean patients,
14/35 patients (46%) have p53 mutations. In patients from Texas,
mutations have been found so far in 3/22 patients (14%), although
additional studies are in progress.
In addition, wild-type p53 has been cloned to produce reagent materials
for other studies, including studying the binding of p53 to cellular
proteins and nucleotides.
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会议论文
ROLE OF HEPATITIS B VIRUS IN HEPATOCELLULAR CARCINOMA
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批准号:5201586
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:E TABOR
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依托单位:
EPIDEMIOLOGY AND PATHOGENESIS OF HEPATITIS B AND C VIRUS
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批准号:6547865
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:E TABOR
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依托单位:
ROLE OF TRANSFORMING GROWTH FACTOR IN HEPATOCARCINOGENESISALPHA
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批准号:3774912
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:E TABOR
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依托单位:
HEPATOCELLULAR CARCINOMA IN CHIMPANZEES
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批准号:3838499
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:E TABOR
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依托单位:
ONCOGENE EXPRESSION IN CELL LINES DERIVED FROM HUMAN HEPATOCELLULAR CARCINOMA
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批准号:3853543
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:E TABOR
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依托单位:
EPIDEMIOLOGY AND PATHOGENESIS OF HEPATITIS B AND C VIRUSES
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批准号:2456640
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:E TABOR
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依托单位:
TUMOR SUPPRESSOR GENES IN HUMAN HEPATOCELLULAR CARCINOMA
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批准号:3774899
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:E TABOR
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依托单位:
ROLE OF HEPATITIS C VIRUS IN HEPATOCELLULAR CARCINOMA
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批准号:3774941
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:E TABOR
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依托单位:
PCR FOR DETECTION OF HEPATITIS B VIRUS IN SERA FROM PATIENTS WITH HCC
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批准号:3853588
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:E TABOR
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依托单位:
EFFECT OF HEPATITIS B VIRUS ON TRANSFORMING GROWTH FACTOR ALPHA
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批准号:3838498
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:E TABOR
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依托单位:
TUMOR SUPPRESSOR GENES IN HUMAN HEPATOCELLULAR CARCINOMA
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批准号:5201547
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:E TABOR
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依托单位:
EPIDEMIOLOGY AND PATHOGENESIS OF HEPATITIS B AND C VIRUSES
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批准号:6161360
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:E TABOR
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依托单位:
ROLE OF TRANSFORMING GROWTH FACTOR ALPHA IN HEPATOCARCINOGENESIS
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批准号:3752750
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:E TABOR
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依托单位:
IMMUNOHISTOCHEMICAL STUDIES OF HUMAN HEPATOCELLULAR CARCINOMA
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批准号:3838475
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:E TABOR
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依托单位:
DEVELOPMENT OF SYSTEMS TO DETECT PCR CONTAMINATION
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批准号:3853587
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:E TABOR
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依托单位:
INHIBITION BY DESFERRIOXAMINE OF IN VITRO REPLICATION OF HIV-1
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批准号:3853590
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:E TABOR
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依托单位:
INHIBITION OF HEPATOCELLULAR CARCINOMA BY DEFEROXAMINE
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批准号:3853544
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:E TABOR
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依托单位:
ROLE OF TRANSFORMING GROWTH FACTOR ALPHA IN HEPATOCARCINOGENESIS
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批准号:5201557
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:E TABOR
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依托单位:
ROLE OF HEPATITIS C VIRUS IN HEPATOCELLULAR CARCINOMA
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批准号:5201573
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:E TABOR
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依托单位:
INHIBITION OF HEPATOCELLULAR CARCINOMA BY DEFEROXAMINE
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批准号:3874789
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:E TABOR
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依托单位:
国内基金
海外基金
大肠癌发生机制的adenoma-adenocarcinoma pathway同serrated pathway的关系的研究
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批准号:30840003
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项目类别:专项基金项目
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资助金额:12.0万元
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批准年份:2008
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负责人:焦宇飞
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依托单位: