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EPIDEMIOLOGY AND PATHOGENESIS OF HEPATITIS B AND C VIRUSES

EPIDEMIOLOGY AND PATHOGENESIS OF HEPATITIS B AND C VIRUSES
乙型和丙型肝炎病毒的流行病学和发病机制
批准号:
2456640
负责人:
E TABOR
金额:
$0.0万
依托单位国家:
美国
项目类别:
财政年份:
--
资助国家:
美国
项目状态:
未结题
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中文摘要
翻译
丙型肝炎病毒(HCV)在日本高度流行,这提供了 理想的学习环境。 在一项队列研究中, HCV和人嗜T淋巴细胞病毒I型(HTLV-I)在一个实验室中进行了研究。 两种病毒都流行的日本地区。 肝癌死亡率为 与HCV抗体(抗HCV)高度相关。 抗HTLV-I抗体 (抗HTLV-I)与HCV感染有一定相关性,但提供了 不会增加患肝癌的风险。 在一项相关的研究中,一组日本人 研究人员对夏威夷的美国人进行了研究,他们都是 在世纪中期HCV流行之前, 日本 肝细胞癌(HCC)与 在该人群中发现了B型肝炎病毒(HBV),但在HCC之间未发现 和HCV;这与日本今天的情况不同,日本80%的HCC 患者有丙型肝炎病毒感染。研究进行了肝癌从 美国确定DNA错配修复缺陷是否可以发挥作用 角色 10例HCC中有4例微卫星不稳定。 的 1例p53外显子多突变的HCC患者, 不稳定性; 5例患者的多个p53内含子改变, HCC(与其自身的非肿瘤性肝脏相比)没有微卫星 不稳定 错配修复缺陷导致微卫星 不稳定性可能在四个肝癌发生中起作用, 这些患者中,但其中3例与p53改变无关。
英文摘要
Hepatitis C virus (HCV) is highly prevalent in Japan, which provides an ideal situation for its study. In a cohort study, the interactions of HCV and human T lymphotropic virus type I (HTLV-I) were studied in an area of Japan where both viruses were endemic. Liver cancer death was highly associated with antibody to HCV (anti-HCV). Antibody to HTLV-I (anti-HTLV-I) was somewhat correlated with HCV infection, but provided no added risk for liver cancer. In a related study, a cohort of Japanese Americans in Hawaii was studied; all were descended from persons who had emigrated from Japan before the mid-twentieth century epidemic of HCV in Japan. A strong association between hepatocellular carcinoma (HCC) and hepatitis B virus (HBV) was found in this population, but not between HCC and HCV; this differs from the situation in Japan today, where 80% of HCC patients have HCV infection.Studies were conducted in HCCs from the United States to determine whether DNA mismatch repair defects could play a role. Microsatellite instability was detected in 4 of 10 HCCs. The one HCC patient with multiple p53 exon mutations had microsatellite instability; five patients with multiple p53 intron alterations in the HCC (compared to their own nontumorous livers) had no microsatellite instability. Mismatch repair defects resulting in microsatellite instability might have played a role in hepatocarcinogenesis in four of these patients, but it was unrelated to p53 alterations in three of them.
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ROLE OF HEPATITIS B VIRUS IN HEPATOCELLULAR CARCINOMA
EPIDEMIOLOGY AND PATHOGENESIS OF HEPATITIS B AND C VIRUS
TUMOR SUPPRESSOR GENES IN HUMAN HEPATOCELLULAR CARCINOMA
ROLE OF TRANSFORMING GROWTH FACTOR IN HEPATOCARCINOGENESISALPHA
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