EPIDEMIOLOGY AND PATHOGENESIS OF HEPATITIS B AND C VIRUSES

乙型和丙型肝炎病毒的流行病学和发病机制

• 批准号: 2456640
• 负责人: E TABOR
• 金额: --
• 依托单位: BUREAU OF HEALTH PLANNING AND RESOURCES DEVELOPMENT
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/2456640
• 关键词: DNA repair; Japanese American; antiviral antibody; cellular oncology; clinical research; epidemiology; gene mutation; hepatitis B virus group; hepatitis C virus; human T cell lymphotropic virus type 1; human tissue; introns; liver neoplasms; pathologic process; tumor suppressor genes; virus infection mechanism; virus related neoplasm /cancer

Hepatitis C virus (HCV) is highly prevalent in Japan, which provides an ideal situation for its study. In a cohort study, the interactions of HCV and human T lymphotropic virus type I (HTLV-I) were studied in an area of Japan where both viruses were endemic. Liver cancer death was highly associated with antibody to HCV (anti-HCV). Antibody to HTLV-I (anti-HTLV-I) was somewhat correlated with HCV infection, but provided no added risk for liver cancer. In a related study, a cohort of Japanese Americans in Hawaii was studied; all were descended from persons who had emigrated from Japan before the mid-twentieth century epidemic of HCV in Japan. A strong association between hepatocellular carcinoma (HCC) and hepatitis B virus (HBV) was found in this population, but not between HCC and HCV; this differs from the situation in Japan today, where 80% of HCC patients have HCV infection.Studies were conducted in HCCs from the United States to determine whether DNA mismatch repair defects could play a role. Microsatellite instability was detected in 4 of 10 HCCs. The one HCC patient with multiple p53 exon mutations had microsatellite instability; five patients with multiple p53 intron alterations in the HCC (compared to their own nontumorous livers) had no microsatellite instability. Mismatch repair defects resulting in microsatellite instability might have played a role in hepatocarcinogenesis in four of these patients, but it was unrelated to p53 alterations in three of them.

丙型肝炎病毒（HCV）在日本非常普遍，这提供了一个