CONTRIBUTION OF NITRIC OXIDE TO REACTIVE HYPEREMIA

一氧化氮导致反应性充血的原因

• 批准号: 3757725
• 负责人: A A QUYYUMI
• 金额: --
• 依托单位: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3757725
• 关键词: analog; arginine; atherosclerosis; blood circulation; blood vessel occlusion; cardiovascular pharmacology; drug screening /evaluation; human subject; ischemia; limbs; muscle relaxation; nitric oxide; reactive hyperemia; stress; vascular endothelium; vascular smooth muscle; vasodilatation; vasodilation; vasodilators

The lining of blood vessels (endothelium) releases a variety of substances that cause the smooth muscle to relax. One important dilator is known as nitric oxide. To study whether nitric oxide is important in reactive hyperemia, we studied the effect of blocking nitric oxide production with L-NMMA in patients with normal coronary arteries and those with hardening of their coronary arteries (atherosclerosis). Reactive hyperemia can be caused by occluding blood supply to a limb temporarily which allows ischemia to occur and then the vasodilatation that follows ischemia is termed reactive hyperemia. The study demonstrated that nitric oxide released during dilation contributes significantly to the magnitude of dilation, and the inhibition of nitric oxide production significantly diminishes the degree of vasodilation that occurs during reactive hyperemia. This suggests that blood vessel dilation during stress is at least partly dependent on the release of nitric oxide.

血管内壁（内皮）释放多种