EFFECT OF L-ARGININE ON ENDOTHELIUM-DEPENDENT CORONARY VASOMOTION

L-精氨酸对内皮依赖性冠状动脉血管舒缩的影响

• 批准号: 3779636
• 负责人: A A QUYYUMI
• 金额: --
• 依托单位: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3779636
• 关键词: arginine; human subject; muscle relaxation; nitric oxide; secretion; spasm; vascular endothelium; vasodilators; vasomotion

The lining of blood vessel is capable of secreting a substance that is capable of causing relaxation of smooth muscle that underlies the lining of blood vessels. This relaxation is important to maintain normal blood vessel tone and deficiency in the secretion of the dilating substance called endothelium-derived relaxant factor, can lead to increase in blood vessel tone which may translate to high blood pressure and spasm of the coronary arteries. L-arginine, and amino acid which is part of the normal diet, is capable of increasing the production of endothelium- derived relaxant factor. In this study we investigated the effect of L- arginine given into the heart arteries to investigate whether this would improve the reduced relaxation blood vessels of the heart. In patients with reduced secretion of endothelium-derived relaxant factor, infusion of arginine helped cause further relaxation.

血管内壁能够分泌一种物质， 能够导致内层平滑肌松弛 的血管。 这种放松对维持正常的血液是很重要的 血管张力和扩张物质分泌不足 称为内皮衍生松弛因子，可导致血液中 血管紧张，这可能会转化为高血压和痉挛的 冠状动脉 L-精氨酸和氨基酸，其是 正常饮食，能够增加内皮细胞的生成， 导出松弛因子。 在这项研究中，我们研究了L-的影响 精氨酸注入心脏动脉，以研究这是否会 改善心脏血管的舒张功能。 患者 伴有内皮源性松弛因子分泌减少，输注 精氨酸有助于进一步放松。