PERIPHERAL VASCULAR ENDOTHELIAL DYSFUNCTION AND MULTIPLE CORONARY RISK FACTORS

外周血管内皮功能障碍和多种冠状动脉危险因素

• 批准号: 3779637
• 负责人: A A QUYYUMI
• 金额: --
• 依托单位: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3779637
• 关键词: atherosclerosis; coronary disorder; disease /disorder proneness /risk; heart catheterization; human subject; muscle relaxation; nitric oxide; peripheral blood vessel disorder; vasodilators

The lining of blood vessels is capable of releasing substances which cause smooth muscle relaxation. These substances are called endothelium- derived relaxant factors. A variety of different conditions are thought to cause dysfunction of endothelium-derived relaxant factor release. In patients undergoing cardiac catheterization, we investigated whether factors that are associated with development of coronary artery disease also cause dysfunction of the lining of blood vessels (endothelium). Increasing age, high cholesterol levels, history of high blood pressure, diabetes and smoking were correlated with the function of the blood vessels in the leg. It was found that people with multiple risk factors had depressed release of endothelium-derived relaxant factor. This suggests that exposure to multiple risk factors for atherosclerosis may lead to dysfunction of the lining of blood vessels.

血管内壁能够释放出 导致平滑肌松弛 这些物质被称为内皮细胞- 衍生松弛因子。 各种不同的条件被认为 导致内皮源性舒张因子释放功能障碍。 在 接受心导管插入术的患者，我们调查了 与冠状动脉疾病发展相关的因素 还引起血管内层（内皮）的功能障碍。 年龄增长，高胆固醇水平，高血压史， 糖尿病和吸烟与血液功能相关 腿上的血管 结果发现，有多种危险因素的人 抑制内皮源性舒张因子的释放。 这 提示暴露于动脉粥样硬化的多种危险因素可能 导致血管内壁功能障碍。