PLATELET INHIBITORY EFFECT OF ENDOTHELIUM-DERIVED RELAXING FACTOR

血管的内层会释放包括一氧化氮在内的松弛因子 氧化物不仅能使血管中的平滑肌细胞 放松，但是，通过扩散到血液中，一氧化氮可以引起 减少了血小板相互粘连的难度。我们 调查了这种现象是否发生在人的心脏上，并 外周循环。研究表明，输注 乙酰胆碱，一种促进体内一氧化氮释放的药物 血管衬里，导致循环血小板水平升高 GMP，一种抑制血小板相互粘连的化合物。这 有硬化(动脉粥样硬化)的患者的影响减弱 心脏或腿部循环中的血管。这项研究因此 提供了支持一氧化氮抑制能力的证据 防止血小板聚集，从而减少血栓的发生 在血管内形成。这也证明了功能障碍 伴随着冠状动脉疾病的血管内层， 可能易于发生凝血。

The lining of blood vessels releases relaxing factors including nitric oxide that not only cause smooth muscle cells of the blood vessels to relax but, by diffusion into the blood stream, nitric oxide can cause reduction in the ease with which platelets stick to each other. We investigated whether this phenomenon occurs in the human heart and peripheral circulation. The study demonstrated that infusion of acetylcholine, a drug that promotes release of nitric oxide from the lining of blood vessels, caused increase in the platelet level of cyclic GMP, a compound that inhibits platelets sticking to each other. This effect was diminished in patients who had hardening (atherosclerosis) of the blood vessels in the heart or in the leg circulation. The study thus provides evidence in favor of the ability of nitric oxide to inhibit platelets from aggregating and thus reducing the incidence of clot formation inside blood vessels. It also demonstrates that dysfunction of the lining of blood vessels that accompanies coronary artery disease, might predispose to the ease with which clotting occurs.