PLATELET INHIBITORY EFFECT OF ENDOTHELIUM-DERIVED RELAXING FACTOR

内皮源性舒张因子的血小板抑制作用

• 批准号: 3757722
• 负责人: A A QUYYUMI
• 金额: --
• 依托单位: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3757722
• 关键词: acetylcholine; blood circulation; blood vessel disorder; cardiovascular pharmacology; coronary disorder; cyclic GMP; heart circulation; human subject; injection /infusion; leg; muscle relaxation; nitric oxide; platelet aggregation inhibitors; vascular endothelium permeability; vascular smooth muscle; vasodilators

The lining of blood vessels releases relaxing factors including nitric oxide that not only cause smooth muscle cells of the blood vessels to relax but, by diffusion into the blood stream, nitric oxide can cause reduction in the ease with which platelets stick to each other. We investigated whether this phenomenon occurs in the human heart and peripheral circulation. The study demonstrated that infusion of acetylcholine, a drug that promotes release of nitric oxide from the lining of blood vessels, caused increase in the platelet level of cyclic GMP, a compound that inhibits platelets sticking to each other. This effect was diminished in patients who had hardening (atherosclerosis) of the blood vessels in the heart or in the leg circulation. The study thus provides evidence in favor of the ability of nitric oxide to inhibit platelets from aggregating and thus reducing the incidence of clot formation inside blood vessels. It also demonstrates that dysfunction of the lining of blood vessels that accompanies coronary artery disease, might predispose to the ease with which clotting occurs.

血管内壁释放放松因子，包括一氧化氮 氧化物不仅导致血管平滑肌细胞 但是，通过扩散到血液中，一氧化氮可以引起 减少血小板彼此粘附的容易性。 我们 研究了这种现象是否发生在人类心脏中， 外周循环 研究表明， 乙酰胆碱，一种促进一氧化氮释放的药物， 血管内壁，引起循环血小板水平增加 GMP，一种抑制血小板相互粘附的化合物。 这 在患有硬化（动脉粥样硬化）的患者中， 心脏或腿部循环的血管。 因此，研究 提供了支持一氧化氮抑制 防止血小板聚集，从而降低血栓的发生率 在血管内形成。 这也证明了功能障碍 冠状动脉疾病的血管内膜 可能容易导致凝血。