CIRCADIAN VARIATION OF TRANSIENT ISCHEMIA AND ISCHEMIC THRESHOLD IN FEMALE PTS

女性 PTS 短暂性缺血和缺血阈值的昼夜变化

• 批准号: 3757724
• 负责人: A A QUYYUMI
• 金额: --
• 依托单位: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3757724
• 关键词: circadian rhythms; coronary occlusion /thrombosis; coronary vessels; electrocardiography; female; gender difference; heart circulation; heart disorder; heart rate; human subject; myocardial ischemia /hypoxia; patient monitoring device; transient ischemic attack

When blood supply to the heart is restricted because of narrowing of the coronary arteries, myocardial ischemia develops which is often not accompanied by chest pain. These episodes can be measured by continuous monitoring of the ECG by using the Holter monitor. Although much information is available about the occurrence of ischemia in male patients with coronary artery disease, whether female patients have differences compared to males has not been studied. We have performed Holter monitoring in 25 women with coronary artery disease and measured the frequency and distribution of the ischemic episodes according to time of day, and the heart rate at which these episodes occur and compared them against male patients. The circadian variation in ischemic episodes with a morning surge, a daytime plateau and a nighttime trough is similar in female patients as male. Ischemia develops at a lower heart rate in the early morning hours compared to other times of the day. This is again similar to male patients.

当心脏的血液供应因狭窄而受到限制时， 冠状动脉，心肌缺血的发展，这往往不是 伴随着胸痛。 这些事件可以通过连续的 使用霍尔特监护仪监测ECG。 虽然大部分 可获得关于在男性中缺血发生的信息 冠心病患者，女性患者是否有 与男性相比的差异尚未研究。 我们已执行 25例女性冠心病患者霍尔特动态心电图监测及测量 根据时间的缺血发作的频率和分布 以及这些事件发生时的心率，并将 针对男性患者。 缺血发作的昼夜节律变化 上午的浪涌，白天的高原和夜间的低谷是相似的 女性患者与男性患者一样。 缺血在较低的心率下发展， 与一天中的其他时间相比，清晨的时间。 这是 与男性患者相似。