ENDOTHELIAL DYSFUNCTION IN PATIENTS WITH MICROVASCULAR ANGINA

被称为内皮的血管衬里能够分泌 允许血管扩张的物质对几种 刺激物。一种因子被称为内皮衍生松弛因子(EDRF)。 乙酰胆碱能够促进血管释放EDRF，并 当内皮受损时，对乙酰胆碱的反应是 被削弱了。许多患者，特别是冠状动脉正常的女性 动脉，因心绞痛性胸痛而出现的小血管异常 心脏中的血管。来调查这些异常是否 是由于内皮功能障碍，我们给它注入了乙酰胆碱 仅在内皮和血管内皮细胞正常的患者中松弛血管 硝普钠，不依赖内皮细胞，松弛血管 功能。大约40%的心绞痛患者尽管正常 冠状动脉有明显的小血管内皮功能障碍 心脏中的血管。这种情况发生的比例与 有高血压和无高血压的患者。

The blood vessel lining known as the endothelium is capable of secreting substances which allow blood vessels to dilate in response to several stimuli. One factor is called endothelium derived relaxant factor (EDRF). Acetylcholine is able to promote release of EDRF from blood vessels and when endothelium is damaged, then the response to acetylcholine is diminished. A number of patients, especially women with normal coronary arteries, suffer anginal chest pain due to abnormalities of the small blood vessels in the heart. To investigate whether these abnormalities are due to dysfunctional endothelium, we infused acetylcholine which relaxes blood vessels only in patients with normal endothelium and nitroprusside which relaxes blood vessels independent of endothelial function. Approximately 40% of patients with angina despite normal coronary arteries had demonstrable endothelial dysfunction of the small blood vessels in their heart. This occurred in equal proportion of patients with and without high blood pressure.