ENDOTHELIAL DYSFUNCTION IN PATIENTS WITH MICROVASCULAR ANGINA

微血管心绞痛患者的内皮功能障碍

• 批准号: 3843412
• 负责人: A A QUYYUMI
• 金额: --
• 依托单位: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3843412
• 关键词: acetylcholine; angina pectoris; blood vessel disorder; female; human subject; microcirculation; nitric oxide; nitroferricyanide; vascular endothelium; vasodilators

The blood vessel lining known as the endothelium is capable of secreting substances which allow blood vessels to dilate in response to several stimuli. One factor is called endothelium derived relaxant factor (EDRF). Acetylcholine is able to promote release of EDRF from blood vessels and when endothelium is damaged, then the response to acetylcholine is diminished. A number of patients, especially women with normal coronary arteries, suffer anginal chest pain due to abnormalities of the small blood vessels in the heart. To investigate whether these abnormalities are due to dysfunctional endothelium, we infused acetylcholine which relaxes blood vessels only in patients with normal endothelium and nitroprusside which relaxes blood vessels independent of endothelial function. Approximately 40% of patients with angina despite normal coronary arteries had demonstrable endothelial dysfunction of the small blood vessels in their heart. This occurred in equal proportion of patients with and without high blood pressure.

被称为内皮的血管衬里能够分泌 允许血管扩张的物质，以响应几个 刺激。 一种因子被称为内皮源性松弛因子（EDRF）。 乙酰胆碱能够促进EDRF从血管释放， 当内皮受损时，对乙酰胆碱的反应是 减少了 许多患者，尤其是冠状动脉正常的女性， 动脉，遭受心绞痛胸痛由于异常的小 心脏中的血管 为了研究这些异常是否 是由于内皮功能失调，我们注入乙酰胆碱， 仅在内皮正常的患者中松弛血管， 硝普钠，不依赖于内皮舒张血管 功能 大约40%的心绞痛患者，尽管正常 冠状动脉有明显的内皮功能障碍， 心脏里的血管 这种情况发生在同等比例的 有无高血压的患者。