PERIPHERAL VASCULAR ENDOTHELIAL DYSFUNCTION IN SYNDROME X

X 综合征中的外周血管内皮功能障碍

• 批准号: 3779639
• 负责人: A A QUYYUMI
• 金额: --
• 依托单位: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3779639
• 关键词: angina pectoris; blood vessel disorder; human subject; nitric oxide; peripheral nervous system disorders; vascular endothelium; vasodilators

We have previously demonstrated that certain patients with chest pain, despite having normal coronary arteries, have a malfunction of the lining of the blood vessels (endothelial dysfunction). To investigate if this abnormality in the lining of blood vessels is restricted to the heart or is a wide-spread phenomenon involving the peripheral circulation, we measured the capability of the endothelium to release endothelium-derived relaxant factor both in the heart and the leg vessels. There was a correlation between the responses in the two beds, suggesting that the dysfunction of the lining of blood vessels is generalized, and involves both vascular beds.

我们以前已经证明，某些胸痛患者， 尽管有正常的冠状动脉， 内皮功能障碍（endothelial dysfunction） 去调查这个 血管内膜的异常仅限于心脏，或 是一种广泛存在的涉及外周循环的现象，我们 测量内皮释放内皮源性 心脏和腿部血管中都有松弛因子。 有一个 两层反应之间的相关性，表明 血管内层的功能障碍是普遍的， 都是血管床