REGIONAL BLOOD FLOW RESPONSES DURING EXERCISE IN CORONARY ARTERY DISEASE

冠状动脉疾病运动期间的局部血流反应

• 批准号: 3779642
• 负责人: A A QUYYUMI
• 金额: --
• 依托单位: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3779642
• 关键词: atherosclerosis; bradycardia; coronary disorder; electrocardiographic monitor; exercise; heart circulation; human subject; positron emission tomography; psychological stressor; spasm

Some patients with angina due to narrowing of the coronary arteries can develop chest pain both at rest, during periods of psychologic stress, and during exercise. Monitoring the frequency of angina with continuous electrocardiography using a Holter monitor demonstrates that the majority of episodes are silent and not perceived by the individual and many occur at relatively low heart rates. To investigate the role of spasm or narrowing of blood vessels in precipitating angina, we studied patients with narrowing of the coronary arteries during rest and exercise and after mental stress induced by playing a video game and measured blood flow using positron emission tomography. A subset of patients developed narrowing of blood vessels with exercise which resulted in reduced blood supply to the heart muscle and precipitated ischemia (angina) at low heart rates. We are currently investigating the effects of mental stress in producing spasm, and the effect of drug therapy.

一些由于冠状动脉狭窄而导致心绞痛的患者， 在休息时，在心理压力期间， 和运动时。 连续监测心绞痛的频率 使用霍尔特监测器的心电图显示，大多数 的情节是无声的，不被个人感知，许多发生 心率相对较低。 研究痉挛或 血管狭窄的心绞痛，我们研究了患者 在休息和运动时冠状动脉狭窄， 在玩电子游戏引起精神压力后， 流动使用正电子发射断层扫描。 一部分患者 运动导致血管狭窄， 供应到心肌和沉淀缺血（心绞痛）在低 心率 我们目前正在研究精神压力的影响 在产生痉挛方面，以及药物治疗的效果。