REGIONAL BLOOD FLOW RESPONSES DURING EXERCISE IN CORONARY ARTERY DISEASE

一些冠状动脉狭窄引起的心绞痛患者可以 在休息时，在心理应激期， 以及在锻炼过程中。连续监测心绞痛发作频率 使用动态心电图仪的心电图显示，大多数人 %的情节是无声的，个人不会察觉，而且许多情节都会发生 在相对较低的心率下。为了研究痉挛或痉挛的作用 突发性心绞痛的血管狭窄，我们研究了患者 在休息和运动时冠状动脉变窄 在玩电子游戏和测量血液引起的精神压力后 流动使用正电子发射断层扫描。出现了一组患者 运动使血管变窄，从而导致血液减少 低血压时对心肌的供应和诱发的缺血(心绞痛) 心率。我们目前正在研究精神压力的影响 在产生痉挛方面，以及药物治疗的效果。

Some patients with angina due to narrowing of the coronary arteries can develop chest pain both at rest, during periods of psychologic stress, and during exercise. Monitoring the frequency of angina with continuous electrocardiography using a Holter monitor demonstrates that the majority of episodes are silent and not perceived by the individual and many occur at relatively low heart rates. To investigate the role of spasm or narrowing of blood vessels in precipitating angina, we studied patients with narrowing of the coronary arteries during rest and exercise and after mental stress induced by playing a video game and measured blood flow using positron emission tomography. A subset of patients developed narrowing of blood vessels with exercise which resulted in reduced blood supply to the heart muscle and precipitated ischemia (angina) at low heart rates. We are currently investigating the effects of mental stress in producing spasm, and the effect of drug therapy.