EFFECTS OF ENDOTHELIUM-DERIVED RELAXANT FACTOR ON CORONARY RESISTANCE VESSELS

内皮源性舒张因子对冠状动脉阻力血管的影响

• 批准号: 3899266
• 负责人: A A QUYYUMI
• 金额: --
• 依托单位: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3899266
• 关键词: acetylcholine; angina pectoris; arm; coronary artery; growth factor; heart circulation; heart pharmacology; human subject; hypertension; hypertrophic myocardiopathy; myocardial ischemia /hypoxia; vascular endothelium; vascular resistance

We have previously demonstrated that the forearm vasculature of hypertensive patients is less responsive to the effects of infused acetylcholine (Ach) which causes the endothelium to release endothelium-- derived-relaxant factor (EDRF). In this study, we investigated the effect of Ach on the endothelium lining of coronary conductance and resistance vessels in patients with various chest pain syndromes. The effects of intracoronary Ach on epicardial coronary diameter, flow and coronary resistance in 16 pts with normal epicardial coronary arteries and chest pain, and those with normal epicardial coronary arteries and hypertrophic cardiomyopathy were studied. Epicardial coronary artery diameter did not change significantly. However, GCV flow increased and coronary vascular resistance decreased incrementally to Ach. At 10-8 molar dose of Ach, GCV flog increased by 12+3%; at 10-7 molar, GCV flow increased by 34+6%; at 10-6 molar dose, it increased by 49+9%. compared to baseline. This suggests that endothelium-dependent dilation of coronary resistance vessels occurs independent of epicardial coronary artery changes. Thus, it is conceivable that the endothelium may regulate coronary resistance and flow in man. It remains to be determined whether abnormalities of vasodilatation of resistance vessels my be secondary to endothelial dysfunction, and thus contribute to myocardial ischemic syndromes in some pts.

我们以前已经证明，前臂血管的 高血压患者对输注的药物的反应较低， 乙酰胆碱（Ach）会导致内皮细胞释放内皮细胞-- 衍生松弛因子（EDRF）。在这项研究中，我们调查了 乙酰胆碱对冠状动脉内皮细胞传导和阻力的影响 各种胸痛综合征患者的血管。 冠状动脉内注射Ach对心外膜冠状动脉内径、流量及血流动力学的影响 16例心外膜冠状动脉正常患者的冠状动脉阻力， 胸痛，心外膜冠状动脉正常， 研究了肥厚型心肌病。心外膜冠状动脉 直径没有显著变化。然而，GCV流量增加， 冠状动脉血管阻力随Ach增加而逐渐降低。在10-8摩尔 Ach剂量时，GCV流量增加了12 ± 3%;在10-7摩尔时，GCV流量增加了 在10-6摩尔剂量下，它增加了49 ± 9%。与基线相比。 这表明冠状动脉阻力的内皮依赖性舒张 心外膜冠状动脉的变化是独立的。因此 可以想象，内皮可以调节冠状动脉阻力， 在人的流动。它仍然有待确定是否异常的 阻力血管的血管舒张可能继发于内皮 功能障碍，从而有助于心肌缺血综合征，在一些 重量份