IMMUNE RESPONSE OF HCV INFECTION

HCV 感染的免疫反应

• 批准号: 3774465
• 负责人: J W SHIH
• 金额: --
• 依托单位: CLINICAL CENTER
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3774465
• 关键词: antiviral antibody; chronic disease /disorder; communicable disease diagnosis; disease /disorder prevention /control; epitope mapping; hepatitis C virus; human subject; microorganism immunology; neutralizing antibody; serology /serodiagnosis; virus antigen; virus protein

This is a continued effort of collaborative multi-phase project to investigate the immune response in both human and experimental animals after the infection with human hepatitis C virus. In the initial phase, the commercial testing kits will be used to detect antibodies to HCV proteins in the known non-A, non-B hepatitis patient sera. This will provide information on the serological data of hepatitis C virus infection and its relationship to other clinical determinations. The second phase of the study will be concentrated on the identification of immune dominant epitopes and neutralizing epitopes. The scope of this phase of study will be extensive and time-consuming. The third phase of the project will encompass using the knowledge of immune response to develop preventive strategy and understanding the pathogenicity of this viral infection. Special attention will be paid to the possible relationship between immune response and the high chronicity in patients.

这是一个持续努力的多阶段协作项目