IMMUNE RESPONSE OF HCV INFECTION

这是一个多阶段合作项目的持续努力， 研究人类和实验动物的免疫反应 在感染人类丙型肝炎病毒后。在初始阶段， 商用检测试剂盒将用于检测HCV抗体 已知的非甲非乙型肝炎患者血清中的蛋白质。这将 提供丙型肝炎病毒感染的血清学资料 及其与其他临床测定的关系。第二阶段 本研究将集中在免疫显性的鉴定上 表位和中和表位。本阶段研究的范围将 是广泛和耗时的。该项目的第三阶段将 包括利用免疫反应的知识， 战略和了解这种病毒感染的致病性。 将特别注意免疫与 反应和患者的高慢性化。

This is a continued effort of collaborative multi-phase project to investigate the immune response in both human and experimental animals after the infection with human hepatitis C virus. In the initial phase, the commercial testing kits will be used to detect antibodies to HCV proteins in the known non-A, non-B hepatitis patient sera. This will provide information on the serological data of hepatitis C virus infection and its relationship to other clinical determinations. The second phase of the study will be concentrated on the identification of immune dominant epitopes and neutralizing epitopes. The scope of this phase of study will be extensive and time-consuming. The third phase of the project will encompass using the knowledge of immune response to develop preventive strategy and understanding the pathogenicity of this viral infection. Special attention will be paid to the possible relationship between immune response and the high chronicity in patients.