IMMUNE RESPONSE OF HCV INFECTION
IMMUNE RESPONSE OF HCV INFECTION
批准号:
6161489
负责人:
J W SHIH
金额:
$0.0万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
--
资助国家:
美国
项目状态:
未结题
起止时间:
至
关键词:
antiviral antibody chronic disease /disorder clinical research communicable disease diagnosis epitope mapping hepatitis C hepatitis C virus hepatitis vaccine human subject laboratory mouse microorganism immunology serology /serodiagnosis synthetic vaccines virus antigen virus infection mechanism virus protein
中文摘要
这是一个持续努力的多阶段协作项目
英文摘要
This is a continuous effort of a collaborative multi-phase project to
investigate the immune response in both humans and experimental animals
after their infection with human hepatitis C virus. In the initial phase,
the commercial testing kits were used to detect antibodies to HCV proteins
in the known non-A, non-B hepatitis patient sera. This provided
information on the serological data of hepatitis C virus infection and its
relationship to other clinical determinations. The second phase of the
study will concentrate on the identification of immune dominant epitopes
and neutralizing epitopes. The scope of this phase of study will be
extensive and time-consuming. The third phase of the project will
encompass using the knowledge of the immune response to develop preventive
strategy and understanding of the pathogenicity of this viral infection.
Special attention will be paid in identifying the possible relationship
between the immune response and the high chronicity in HCV infected
patients. One part of this study is to transfer techniques and procedures
developed in the laboratory studies to our clinical studies. We have
developed a proliferation assay to measure the immune response in mice to
recombinant HCV core proteins. We then adopted the experience learned in
working with mice to develop procedures to differentiate chronic infected
patients from the recovered ones. During FY '95 and FY '96, we initiated
a new project to examine the potential for a nucleic acid vaccine for HCV.
The knowledge, the techniques and the material developed in this nucleic
acid vaccine study will also complement our continued effort in
understanding the immune response in HCV infection. The long-term goal of
both projects will lead to developing models of immune therapy of chronic
viral infection of the liver.
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会议论文
STUDY OF HEPATITIS B VIRUS SURFACE ANTIGEN POLYPEPTIDE COMPONENTS IN SERA
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批准号:4691951
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项目类别:
-
资助金额:$0.0万
-
财政年份:--
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负责人:J W SHIH
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依托单位:
EVALUATION OF NUCLEIC ACID VACCINE AS A PREVENTIVE AND THERAPEUTIC MODALITY
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批准号:2571374
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项目类别:
-
资助金额:$0.0万
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财政年份:--
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负责人:J W SHIH
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依托单位:
MODELING OF HUMAN HBV INFECTION WITH A TRANSFECTED RAT HEPATOMA CELL LINE
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批准号:3874318
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项目类别:
-
资助金额:$0.0万
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财政年份:--
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负责人:J W SHIH
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依托单位:
NUCLEIC ACID VACCINE AS PREVENTIVE AND THERAPEUTIC MODALITY
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批准号:6161493
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:J W SHIH
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依托单位:
CHARACTERIZATION OF HUMAN PATHOGENIC MYCOPLASMA FROM HIV INFECTED PATIENTS
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批准号:5201142
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:J W SHIH
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依托单位:
IMMUNE RESPONSE OF HCV INFECTION
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批准号:3774465
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:J W SHIH
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依托单位:
IMMUNORESPONSE TO THE PRE-S GENE PRODUCT OF HBV
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批准号:3874306
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:J W SHIH
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依托单位:
CHARACTERIZATION OF HUMAN PATHOGENIC MYCOPLASMA FROM HIV INFECTED PATIENTS
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批准号:3752235
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:J W SHIH
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依托单位:
IMMUNE RESPONSE OF HCV INFECTION
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批准号:6103639
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:J W SHIH
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依托单位:
GENE THERAPY FOR HEPATITIS C INFECTION--CHRONIC INFECTIOUS DISEASE MODEL
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批准号:6103644
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:J W SHIH
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依托单位:
IMMUNE RESPONSE OF HCV INFECTION
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批准号:5201146
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:J W SHIH
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依托单位:
CHARACTERIZATION OF A HUMAN PATHOGENIC MYCOPLASMA FROM HIV INFECTED PATIENTS
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批准号:3774460
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:J W SHIH
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依托单位:
STUDY OF HEPATITIS B VIRUS SURFACE ANTIGEN POLYPEPTIDE COMPONENTS IN SERA
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批准号:3963130
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项目类别:
-
资助金额:$0.0万
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财政年份:--
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负责人:J W SHIH
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依托单位:
IMMUNE RESPONSE OF HCV INFECTION
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批准号:3837963
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:J W SHIH
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依托单位:
IMMUNORESPONSE TO THE PRE-S PRODUCT OF HBV
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批准号:3963134
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项目类别:
-
资助金额:$0.0万
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财政年份:--
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负责人:J W SHIH
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依托单位:
MODELING OF HUMAN HBV INFECTION WITH A TRANSFUSION RAT HEPATITIS CELL LINE
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批准号:3837958
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项目类别:
-
资助金额:$0.0万
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财政年份:--
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负责人:J W SHIH
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依托单位:
IMMUNORESPONSE TO THE PRE-S PRODUCT OF HBV
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批准号:4691955
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项目类别:
-
资助金额:$0.0万
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财政年份:--
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负责人:J W SHIH
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依托单位:
QUANTITATIVE ANALYSIS OF VIRAL GENOMES AND THEIR CLINICAL CORRELATIONS
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批准号:6161487
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项目类别:
-
资助金额:$0.0万
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财政年份:--
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负责人:J W SHIH
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依托单位:
GENE THERAPY FOR HEPATITIS C INFECTION--CHRONIC INFECTIOUS DISEASE MODEL
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批准号:6161494
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项目类别:
-
资助金额:$0.0万
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财政年份:--
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负责人:J W SHIH
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依托单位:
MODELING OF HUMAN HBV INFECTION WITH A TRANSFUSION RAT HEPATITIS CELL LINE
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批准号:3774461
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项目类别:
-
资助金额:$0.0万
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财政年份:--
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负责人:J W SHIH
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依托单位: