CHARACTERIZATION OF A HUMAN PATHOGENIC MYCOPLASMA FROM HIV INFECTED PATIENTS

HIV 感染者的人类致病性支原体的特征

• 批准号: 3774460
• 负责人: J W SHIH
• 金额: --
• 依托单位: CLINICAL CENTER
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3774460
• 关键词: HIV infections; Mycoplasma; antimicroorganism antibody; bacterial genetics; communicable disease diagnosis; microorganism classification; microorganism culture; molecular cloning; nucleic acid probes; opportunistic infections; reproductive system disorder diagnosis; solution hybridization; species difference; urinary tract disorder diagnosis; urinary tract infection

The laboratory continues to work on newly identified strains of mycoplasma originated from AIDS patients. One of the isolates: Mycoplasma penetrans, is a new species of mycoplasma isolated from the urogenital tract of patients with AIDS. Genetic analysis of the DNA of this agent by liquid hybridization procedure has shown that this agent is a new species. This organism has properties of adherence, hemadsorption, cytadsorption and invades many different types of mammalian cells. Thus, it was so named: M. penetrans. Specific genetic clones and antibodies against this agent were prepared and were used to probe infected tissues. Attempts have been made to develop molecular and serological assays for the agent and specific immunoresponse to this agent. These assays were used to assess the significance of infectivity and pathogenicity of this agent in human.

实验室继续对新鉴定的支原体菌株进行研究 源自艾滋病患者。其中一个分离株：反式支原体， 是一种新的支原体分离自泌尿生殖道， 艾滋病患者。通过液体分析这种药剂的DNA 杂交结果表明，这是一个新种。这 生物体具有粘附、血细胞吸附、细胞吸附和 侵入许多不同类型的哺乳动物细胞。因此，它被命名为：M。 是的。特异性基因克隆和抗体针对这种代理人， 制备并用于探测感染组织。已经尝试 发展分子和血清学检测方法， 免疫反应。这些试验用于评估 该病原体在人类中感染性和致病性意义。