CHARACTERIZATION OF A HUMAN PATHOGENIC MYCOPLASMA FROM HIV INFECTED PATIENTS

该实验室继续研究新发现的支原体菌株。 起源于艾滋病患者。其中一个分离株：穿透支原体， 是一种新的支原体，分离自猪的泌尿生殖道。 艾滋病患者。该菌剂DNA的液体遗传分析 杂交试验表明，该菌剂为新种。这 生物体具有黏附、血吸附、细胞吸附和 入侵多种不同类型的哺乳动物细胞。因此，它被命名为：M。 穿透者。针对该病原体的特异性基因克隆和抗体 制备并用于探测感染组织。已经进行了一些尝试 建立试剂和特异性的分子和血清学分析方法 对该制剂的免疫反应。这些检测被用来评估 该病原体在人体内的传染性和致病性的意义。

The laboratory continues to work on newly identified strains of mycoplasma originated from AIDS patients. One of the isolates: Mycoplasma penetrans, is a new species of mycoplasma isolated from the urogenital tract of patients with AIDS. Genetic analysis of the DNA of this agent by liquid hybridization procedure has shown that this agent is a new species. This organism has properties of adherence, hemadsorption, cytadsorption and invades many different types of mammalian cells. Thus, it was so named: M. penetrans. Specific genetic clones and antibodies against this agent were prepared and were used to probe infected tissues. Attempts have been made to develop molecular and serological assays for the agent and specific immunoresponse to this agent. These assays were used to assess the significance of infectivity and pathogenicity of this agent in human.