CHARACTERIZATION OF HUMAN PATHOGENIC MYCOPLASMA FROM HIV INFECTED PATIENTS

该实验室继续对新发现的菌株进行研究。 支原体起源于艾滋病患者。其中一种分离株： 穿透性支原体是一种新的支原体，分离自 艾滋病患者的泌尿生殖道。DNA的遗传分析 通过液体杂交程序对该试剂进行的分析表明，这种 智能体是一个新物种。这种有机体具有粘附性， 血吸附，细胞吸附，并入侵许多不同类型的 哺乳动物细胞。因此，它被命名为：穿透支原体。特定的 制备了针对该病原体的基因克隆和抗体 用来探测受感染的组织。已经有人尝试过 发展对该试剂和特异性的分子和血清分析 对该制剂的免疫反应。这些检测被用来评估 这种病原体在人类中的传染性和致病性的意义。 该项目是持续研发工作的一部分。 来调查导致这些疾病的相关因素 艾滋病的发病机制。许多测试和调查程序 在本研究中开发的内容包含在增强功能中或直接 这个实验室的服务能力。

The laboratory continues to work on newly identified strains of mycoplasma originated from AIDS patients. One of the isolates: Mycoplasma penetrans, is a new species of mycoplasma isolated from the urogenital tract of patients with AIDS. Genetic analysis of the DNA of this agent by liquid hybridization procedure has shown that this agent is a new species. This organism has properties of adherence, hemadsorption, cytadsorption and invades many different types of mammalian cells. Thus, it was so named: M. penetrans. Specific genetic clones and antibodies against this agent were prepared and were used to probe infected tissues. Attempts have been made to develop molecular and serological assays for the agent and specific immunoresponse to this agent. These assays were used to assess the significance of infectivity and pathogenicity of this agent in humans. This project is part of the continued research and development effort of this laboratory to investigate the co-factors contributing to the pathogenesis of AIDS. Many of the tests and investigating procedures developed in this study were incorporated in the enhancement or direct service ability of this laboratory.