NUCLEIC ACID VACCINE AS PREVENTIVE AND THERAPEUTIC MODALITY
NUCLEIC ACID VACCINE AS PREVENTIVE AND THERAPEUTIC MODALITY
批准号:
6161493
负责人:
J W SHIH
金额:
$0.0万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
--
资助国家:
美国
项目状态:
未结题
起止时间:
至
中文摘要
这个程序是为了阐明一种新认识的模式
英文摘要
This program was initiated to elucidate a newly recognized modality of
vaccination and to extend our long-term study of the immune response and
clinical sequelae of hepatitis C virus (HCV) infection. One of the
advantages of genetic immunization is that the endogenously expressed
proteins can be recognized by class I MHC molecules and expressed on the
cell surface. The MHC-antigen complex on the cell surface can be
recognized by cytotoxic T lymphocytes (CTL), which in turn are activated
and attack infected cells. The possibility of inducing an immune response
to HCV core protein using DNA immunization provides an attractive
alternative to classic vaccination. There are many problematic issues
related to vaccine development for hepatitis C. One of the major concerns
is the genetic stability of the infectious agent, HCV. There are two
hypervariable regions in the putative HCV envelope proteins. Immune escape
mutants observed were attributed to mutations in these regions.
Experimentally infected chimpanzees and HCV patients were found to have
repeated bouts of infection with either homologous or new strains of HCV.
This-could also be one of the reasons that more than 80% of the infections
become chronic. Directly inducing strong cell-mediated immunity,
especially protective cytotoxic T lymphocyte, may not only help in
preventing initial HCV infection, but may also produce immune modulation
to overcome existing infection. During the past year, we have constructed
several different plasmids containing HCV genes and were able to evaluate
the induction of antibodies to HCV core proteins in mice. We are in the
process of developing assays to measure CTL activity in the mouse model.
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EVALUATION OF NUCLEIC ACID VACCINE AS A PREVENTIVE AND THERAPEUTIC MODALITY
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批准号:2571374
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:J W SHIH
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依托单位:
STUDY OF HEPATITIS B VIRUS SURFACE ANTIGEN POLYPEPTIDE COMPONENTS IN SERA
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批准号:4691951
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:J W SHIH
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依托单位:
MODELING OF HUMAN HBV INFECTION WITH A TRANSFECTED RAT HEPATOMA CELL LINE
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批准号:3874318
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:J W SHIH
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依托单位:
CHARACTERIZATION OF HUMAN PATHOGENIC MYCOPLASMA FROM HIV INFECTED PATIENTS
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批准号:5201142
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:J W SHIH
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依托单位:
IMMUNE RESPONSE OF HCV INFECTION
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批准号:3774465
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:J W SHIH
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依托单位:
IMMUNORESPONSE TO THE PRE-S GENE PRODUCT OF HBV
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批准号:3874306
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:J W SHIH
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依托单位:
IMMUNE RESPONSE OF HCV INFECTION
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批准号:6161489
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:J W SHIH
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依托单位:
CHARACTERIZATION OF HUMAN PATHOGENIC MYCOPLASMA FROM HIV INFECTED PATIENTS
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批准号:3752235
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:J W SHIH
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依托单位:
CHARACTERIZATION OF A HUMAN PATHOGENIC MYCOPLASMA FROM HIV INFECTED PATIENTS
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批准号:3774460
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:J W SHIH
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依托单位:
IMMUNE RESPONSE OF HCV INFECTION
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批准号:3837963
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:J W SHIH
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依托单位:
STUDY OF HEPATITIS B VIRUS SURFACE ANTIGEN POLYPEPTIDE COMPONENTS IN SERA
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批准号:3963130
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:J W SHIH
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依托单位:
IMMUNE RESPONSE OF HCV INFECTION
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批准号:5201146
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:J W SHIH
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依托单位:
IMMUNE RESPONSE OF HCV INFECTION
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批准号:6103639
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:J W SHIH
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依托单位:
GENE THERAPY FOR HEPATITIS C INFECTION--CHRONIC INFECTIOUS DISEASE MODEL
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批准号:6103644
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:J W SHIH
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依托单位:
MODELING OF HUMAN HBV INFECTION WITH A TRANSFUSION RAT HEPATITIS CELL LINE
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批准号:3837958
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:J W SHIH
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依托单位:
QUANTITATIVE ANALYSIS OF VIRAL GENOMES AND THEIR CLINICAL CORRELATIONS
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批准号:6161487
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:J W SHIH
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依托单位:
IMMUNORESPONSE TO THE PRE-S PRODUCT OF HBV
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批准号:3963134
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:J W SHIH
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依托单位:
IMMUNORESPONSE TO THE PRE-S PRODUCT OF HBV
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批准号:4691955
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:J W SHIH
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依托单位:
GENE THERAPY FOR HEPATITIS C INFECTION--CHRONIC INFECTIOUS DISEASE MODEL
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批准号:2456687
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:J W SHIH
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依托单位:
IMMUNE RESPONSE OF HCV INFECTION
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批准号:2571376
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:J W SHIH
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依托单位:
海外基金