IMMUNE RESPONSE OF HCV INFECTION

这是一个协作多阶段项目的持续努力，以 研究人类和实验动物的免疫反应。 感染人类丙型肝炎病毒后。在最初的阶段， 商业检测试剂盒用于检测丙型肝炎病毒蛋白的抗体 在已知的非甲非乙型肝炎患者血清中。这提供了 丙型肝炎病毒感染及其感染的血清学资料 与其他临床检测的关系。第二阶段 研究集中在免疫优势表位的鉴定和 中和表位。这一阶段的研究范围很广， 这很耗时。该项目的第三阶段将包括使用 了解免疫反应以制定预防策略和 了解这种病毒感染的致病性。特价 将注意找出两者之间可能存在的关系 丙型肝炎病毒感染者的免疫反应和高慢性化。在.期间 去年，我们启动了一个新项目，以研究 丙型肝炎核酸疫苗。在此过程中获得的知识和信息 研究对于建立基础来调查 疫苗的研发。在这个过程中发展起来的技术和材料 学习也将相辅相成。的长期目标是 这两个项目都将导致免疫模型的开发 慢性肝小管感染的治疗。

This is a continuous effort on a collaborative multi- phase project to investigate the immune response in both human and experimental animals after the infection with human hepatitis C virus. In the initial phase, the commercial testing kits were used to detect antibodies to HCV proteins in the known non-A, non-B hepatitis patient sera. This provided information on the serological data of hepatitis C virus infection and its relationship to other clinical determination. The second phase of the study concentrated on the identification of immune dominant epitopes and neutralizing epitopes. The scope of this phase of study was extensive and time consuming. The third phase of the project will encompass using the knowledge of immune response to develop preventative strategy and understanding the pathogenicity of this viral infection. Special attentions will be paid to identify the possible relationship between immune response and the high chronicity in HCV infected patients. During the last year, we initiated a new project to examine the potential of a HCV nucleic acid vaccine. The knowledge and information gained in this study were essential for building the foundation to investigate the development of a vaccine. The techniques and material developed in this study will also complement the need for each other. The long-term goal of both projects will lead to the development of models for the immune therapy of chronic vial infection of the liver.