IMMUNE RESPONSE OF HCV INFECTION

HCV 感染的免疫反应

• 批准号: 3837963
• 负责人: J W SHIH
• 金额: --
• 依托单位: CLINICAL CENTER
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3837963
• 关键词: antiviral antibody; chronic disease /disorder; communicable disease control; cooperative study; epitope mapping; hepatitis C virus; human tissue; immunopathology diagnosis; microorganism immunology; serology /serodiagnosis; virus protein

This is a newly initiated collaborative multi-phase project to investigate the immune response in both human and experimental animals after the infection with the human hepatitis C virus. In the initial phase, the commercial testing kits will be used to detect antibodies to HCV proteins in the known non-A, non-B hepatitis patient sera. This will provide information on the serological data of hepatitis C virus infection and its relationship to other clinical determination. The second phase of the study will be concentrated on the identification of immune dominant epitopes and neutralizing epitopes. The scope of this phase of this study will be extensive and time consuming. The third phase of the project will encompass using the knowledge of immune response to develop preventive strategy and understanding the pathogenicity of this viral infection. Special attention will be paid to the possible relationship between immune response and the high chronicity in patients.

这是一个新启动的多阶段合作项目，旨在调查 人类和实验动物的免疫反应 感染人类丙型肝炎病毒。 在初始阶段， 商业检测试剂盒将用于检测 HCV 蛋白抗体 在已知的非甲、非乙型肝炎患者血清中。 这将提供 丙型肝炎病毒感染及其相关血清学数据信息 与其他临床测定的关系。 第二阶段 研究将集中于免疫显性的识别 表位和中和表位。 本阶段研究范围 将是广泛且耗时的。 该项目第三期将 包括利用免疫反应知识来制定预防措施 策略并了解这种病毒感染的致病性。 将特别关注免疫之间可能的关系 反应和患者的高度慢性化。