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INHIBITION OF HIV-1 AND HIV-2 WITH ANTISENSE OLIGONUCLEOTIDES AND RIBOZYMES

INHIBITION OF HIV-1 AND HIV-2 WITH ANTISENSE OLIGONUCLEOTIDES AND RIBOZYMES
用反义寡核苷酸和核酶抑制 HIV-1 和 HIV-2
批准号：
3792576
负责人：
I K HEWLETT
金额：
$0.0万
依托单位：
CENTER BIOLOGICS EVALUATION RESEARCH TRANSFUSION
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/3792576
关键词：
AIDS antiAIDS agent antisense nucleic acid human immunodeficiency virus 1 human immunodeficiency virus 2 liposomes polymerase chain reaction ribozymes tissue /cell culture virus antigen zidovudine

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中文摘要
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英文摘要
Phosphorothioate modified antisense oligonucleotides (ASOs) have been designed complementary to various regulatory and structural genes of HIV-1. These ASOs are being evaluated for their anti-HIV activity using H9 and U937 cells as target cells. Antiviral activity is being assessed by p24 antigen and PCR. Preliminary results suggest that ASOs from the tat and the LTR regions were most effective in inhibiting virus expression. These ASOs are being packaged into liposomes and administered either singly or in combination with other ASOs or with AZT to target cells and their antiviral activity evaluated. Similar experiments are being performed with HIV-2. Oligonucleotides that allow the formation of ribozyme complexes or that interact with b-ribbon motifs on DNA are also being evaluated for their antiviral activity against HIV-1 and HIV-2.
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VIRUS-CELL INTERACTIONS AND HOST FACTORS IN HIV PATHOGENESIS
CELLULAR PATHWAYS INVOLVED IN VIRAL INDUCTION--THEIR ROLE IN HIV PATHOGENESIS
RAPID AND QUANTITATIVE DETECTION BY PCR OF HIV-1 SPECIFIC DNA AND RNA
DETECTION OF MULTIPLE VIRUSES BY PCR
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