VIRAL ETIOLOGY OF AIDS ASSOCICATED KAPOSI'S SARCOMA IN HIV NEGATIVE INDIVIDUALS

HIV 阴性个体中与艾滋病相关的卡波西肉瘤的病毒病因学

• 批准号: 3792605
• 负责人: I K HEWLETT
• 金额: --
• 依托单位: CENTER BIOLOGICS EVALUATION RESEARCH TRANSFUSION
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3792605
• 关键词: AIDS; Kaposi's sarcoma; Mycobacterium tuberculosis; human immunodeficiency virus; human subject; immunodeficiency; polymerase chain reaction; serology /serodiagnosis; tuberculosis; virus related neoplasm /cancer

The HIV status of a 42 year old homosexual male, who was seronegative, but had symptoms of Kaposi's Sarcoma was determined by PCR. This individual was PCR -ve and Ab -ve. RNA-PCR on peripheral blood lymphocytes using tat primers also yielded negative results, suggesting that this may be a case of KS in the absence of HIV infection. A second case was evaluated where a patient with low CD4 counts and disseminated tuberculosis was negative for HIV by PCR and serologic tests. At present experiments are in progress to study the role of other viruses in Kaposi's Sarcoma in patients with immune deficiency.

一名42岁男同性恋者，血清检测呈阴性，