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VIRAL ETIOLOGY OF AIDS ASSOCICATED KAPOSI'S SARCOMA IN HIV NEGATIVE INDIVIDUALS

VIRAL ETIOLOGY OF AIDS ASSOCICATED KAPOSI'S SARCOMA IN HIV NEGATIVE INDIVIDUALS
HIV 阴性个体中与艾滋病相关的卡波西肉瘤的病毒病因学
批准号：
3792605
负责人：
I K HEWLETT
金额：
$0.0万
依托单位：
CENTER BIOLOGICS EVALUATION RESEARCH TRANSFUSION
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/3792605
关键词：
AIDS Kaposi's sarcoma Mycobacterium tuberculosis human immunodeficiency virus human subject immunodeficiency polymerase chain reaction serology /serodiagnosis tuberculosis virus related neoplasm /cancer

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中文摘要
翻译
一名42岁的同性恋男性的艾滋病毒状况，他是血清阴性的， 但有卡波西肉瘤症状的患者。 这 个体为PCR-ve和Ab-ve。 外周血RNA-PCR 使用tat引物的淋巴细胞也得到阴性结果，表明 这可能是一个没有艾滋病毒感染的KS病例。 一 评价了第二个病例，其中患者具有低CD4计数， 播散型结核病经PCR和血清学检测均为HIV阴性 试验. 目前正在进行实验，以研究 免疫缺陷患者卡波西肉瘤中的其他病毒。
英文摘要
The HIV status of a 42 year old homosexual male, who was seronegative, but had symptoms of Kaposi's Sarcoma was determined by PCR. This individual was PCR -ve and Ab -ve. RNA-PCR on peripheral blood lymphocytes using tat primers also yielded negative results, suggesting that this may be a case of KS in the absence of HIV infection. A second case was evaluated where a patient with low CD4 counts and disseminated tuberculosis was negative for HIV by PCR and serologic tests. At present experiments are in progress to study the role of other viruses in Kaposi's Sarcoma in patients with immune deficiency.
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会议论文
VIRUS-CELL INTERACTIONS AND HOST FACTORS IN HIV PATHOGENESIS
CELLULAR PATHWAYS INVOLVED IN VIRAL INDUCTION--THEIR ROLE IN HIV PATHOGENESIS
RAPID AND QUANTITATIVE DETECTION BY PCR OF HIV-1 SPECIFIC DNA AND RNA
DETECTION OF MULTIPLE VIRUSES BY PCR
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