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VIRAL ETIOLOGY OF AIDS ASSOCICATED KAPOSI'S SARCOMA IN HIV NEGATIVE INDIVIDUALS

VIRAL ETIOLOGY OF AIDS ASSOCICATED KAPOSI'S SARCOMA IN HIV NEGATIVE INDIVIDUALS
HIV 阴性个体中与艾滋病相关的卡波西肉瘤的病毒病因学
批准号：
3792605
负责人：
I K HEWLETT
金额：
$0.0万
依托单位：
CENTER BIOLOGICS EVALUATION RESEARCH TRANSFUSION
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/3792605
关键词：
AIDS Kaposi's sarcoma Mycobacterium tuberculosis human immunodeficiency virus human subject immunodeficiency polymerase chain reaction serology /serodiagnosis tuberculosis virus related neoplasm /cancer

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中文摘要
翻译
一名血清阴性的42岁男同性恋者的艾滋病毒状况， 但有Kaposi肉瘤症状的患者用聚合酶链式反应(PCR)检测。这 个体为PCRVe和AbVe。外周血中的RNA-PCR检测 使用TAT引物的淋巴细胞也产生了阴性结果，这表明 这可能是一例未感染艾滋病毒的KS病例。一个 对第二个病例进行了评估，其中一名患者的CD4细胞计数较低，并且 经聚合酶链式反应和血清学检测，播散性结核病的HIV呈阴性。 测试。目前正在进行实验研究，以研究其作用 其他病毒在卡波西肉瘤患者中的免疫缺陷。
英文摘要
The HIV status of a 42 year old homosexual male, who was seronegative, but had symptoms of Kaposi's Sarcoma was determined by PCR. This individual was PCR -ve and Ab -ve. RNA-PCR on peripheral blood lymphocytes using tat primers also yielded negative results, suggesting that this may be a case of KS in the absence of HIV infection. A second case was evaluated where a patient with low CD4 counts and disseminated tuberculosis was negative for HIV by PCR and serologic tests. At present experiments are in progress to study the role of other viruses in Kaposi's Sarcoma in patients with immune deficiency.
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会议论文
VIRUS-CELL INTERACTIONS AND HOST FACTORS IN HIV PATHOGENESIS
CELLULAR PATHWAYS INVOLVED IN VIRAL INDUCTION--THEIR ROLE IN HIV PATHOGENESIS
EFFICACY OF PASSIVE IMMUNOTHERAPY IN AIDS ASSESSED BY PCR
IMMUNIZATION WITH HIV IMMUNE GLOBULIN IN THE PREVENTION OF HIV INFECTION IN PAN
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