EFFICACY OF PASSIVE IMMUNOTHERAPY IN AIDS ASSESSED BY PCR
EFFICACY OF PASSIVE IMMUNOTHERAPY IN AIDS ASSESSED BY PCR
批准号:
3804851
负责人:
I K HEWLETT
金额:
$0.0万
依托单位国家:
美国
项目类别:
财政年份:
--
资助国家:
美国
项目状态:
未结题
起止时间:
至
中文摘要
从健康的HIV-1感染个体收集的高免疫血浆
英文摘要
A hyperimmune plasma collected from healthy, HIV-1 infected individuals
with high titers of neutralizing antibodies was administered to 7 AIDS and
3 ARC patients. 500 ml of plasma was administered monthly for 10 months.
All patients were monitored for viral antibodies, antigen and ciral nucleic
acid by PCR. DNA and RNA-PCR was performed on nucleic acid isolated from
serum using primers from the gag region of the HIV-1 genome. HIV-1 DNA and
RNA were detected prior to administration of immunoglobulin in all
patients. No viral nucleic acid could be detected in serum after the first
transfusion in any patient and this remained so for the length of the study
in ARC patients. Viral sequences were detected in 3/7 AIDS patients
towards the end of the trial (10-11 months). HIV antigen was not detected,
except in 2 AIDS patients towards the end of the trial. These results
indicate that hyperimmune plasma eliminated detection of HIV nucleic acid
from the plasma of both AIDS and ARC patients although the effect was not
as sustained in AIDS. Passive immunization may be useful in clearing
plasma viremia, particularly in ARC patients. In a prospective study,
serum and cells from 50 patients enrolled in a controlled study for
evaluation of the therapeutic value of hyperimmune plasma, are being
analyzed by PCR for HIV DNA and RNA.
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会议论文
VIRUS-CELL INTERACTIONS AND HOST FACTORS IN HIV PATHOGENESIS
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批准号:5200814
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项目类别:
-
资助金额:$0.0万
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财政年份:--
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负责人:I K HEWLETT
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依托单位:
CELLULAR PATHWAYS INVOLVED IN VIRAL INDUCTION--THEIR ROLE IN HIV PATHOGENESIS
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批准号:3770409
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:I K HEWLETT
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依托单位:
IMMUNIZATION WITH HIV IMMUNE GLOBULIN IN THE PREVENTION OF HIV INFECTION IN PAN
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批准号:3804852
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:I K HEWLETT
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依托单位:
VIRAL DETERMINANTS OF HIV-1 PATHOGENESIS BY CONSTRUCTION OF RECOMBINANT VIRUSES
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批准号:3804854
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:I K HEWLETT
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依托单位:
RAPID AND QUANTITATIVE DETECTION BY PCR OF HIV-1 SPECIFIC DNA AND RNA
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批准号:3792569
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:I K HEWLETT
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依托单位:
DETECTION OF MULTIPLE VIRUSES BY PCR
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批准号:3792438
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:I K HEWLETT
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依托单位:
INFECTION OF NON-HEMATOPOIETIC CELLS WITH HIV-1 AND HIV-2
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批准号:3792570
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:I K HEWLETT
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依托单位:
EFFICACY OF HYPERIMMUNE PLASMA IN AIDS
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批准号:3792575
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:I K HEWLETT
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依托单位:
VIRAL ETIOLOGY OF AIDS ASSOCICATED KAPOSI'S SARCOMA IN HIV NEGATIVE INDIVIDUALS
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批准号:3792605
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:I K HEWLETT
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依托单位:
NUCLEIC ACID BASED DETECTION AND QUANTITATION OF HIV-1 AND HIV-2
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批准号:3748264
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:I K HEWLETT
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依托单位:
INHIBITION OF HIV-1 AND HIV-2 WITH ANTISENSE OLIGONUCLEOTIDES AND RIBOZYMES
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批准号:3792576
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:I K HEWLETT
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依托单位:
INFECTION OF NON-HEMATOPOIETIC CELLS WITH HIV-1 AND HIV-2
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批准号:3804840
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:I K HEWLETT
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依托单位:
DETECTION OF MULTIPLE VIRUSES BY PCR CO-AMPLIFICATION
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批准号:3804838
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:I K HEWLETT
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依托单位:
INDUCTION OF HIV-1 FROM LATENTLY INFECTED CELL LINES BY CHEMICAL CARCINOGENS
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批准号:3804841
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:I K HEWLETT
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依托单位:
ASSESSMENT OF HIV INFECTION IN SPANISH SERONEGATIVE IVDAS AND THEIR PARTNERS
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批准号:3811156
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:I K HEWLETT
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依托单位:
INFECTION OF NON-HEMATOPOIETIC CELLS WITH HIV-1 AND HIV-2
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批准号:3811160
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:I K HEWLETT
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依托单位:
CELLULAR PATHWAYS INVOLVED IN VIRAL INDUCTION--THEIR ROLE IN HIV PATHOGENESIS
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批准号:3748262
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:I K HEWLETT
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依托单位:
APPLICATION OF GENETIC TECHNIQUES FOR DETECTION OF HIV IN CELLS AND BODY FLUIDS
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批准号:5200816
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:I K HEWLETT
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依托单位:
ANTI-HIV ACTIVITY OF ANTINEOPLASTONS
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批准号:3792594
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:I K HEWLETT
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依托单位:
DETECTION OF HIV BY A MAGNETIC BEAD BASED VIRAL CAPTURE ASSAY
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批准号:3792599
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项目类别:
-
资助金额:$0.0万
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财政年份:--
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负责人:I K HEWLETT
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依托单位:
海外基金