INFECTION OF NON-HEMATOPOIETIC CELLS WITH HIV-1 AND HIV-2
INFECTION OF NON-HEMATOPOIETIC CELLS WITH HIV-1 AND HIV-2
批准号:
3792570
负责人:
I K HEWLETT
金额:
$0.0万
依托单位国家:
美国
项目类别:
财政年份:
--
资助国家:
美国
项目状态:
未结题
起止时间:
至
中文摘要
已知HIV-1可感染多种非淋巴细胞系,
如果入境方式被推定为涉及额外的或
一种独立的受体或第二信使样分子。广度
在这些细胞系中病毒复制的情况与
产生性至流产感染提示宿主依赖控制
关于病毒复制的研究。这些模型系统是识别的理想选择
与再感染有关的细胞和病毒因素。此外,在某些情况下
例如,来自患者的某些上皮细胞(例如结肠、宫颈
等)已被证明含有病毒核酸。最新流行病学
研究表明,某些传播给胎儿的途径可能发生在子宫内。
可能涉及非淋巴细胞类型的感染。我们已经发起了
探索活动性或可能流产病毒机制的研究
这些细胞类型中的感染。我们选择的工作目标单元
人胚胎神经母细胞瘤细胞系SKNSH、SKNMC
L132,两株宫颈癌细胞系SIHA和C33A,两株子宫细胞
细胞系HS 825T和HS 258T,阴道癌细胞系HS 769 VG。这些细胞
LINE已经感染了HIV-1,感染过程正在
被监视着。病毒复制动力学的评价--合成
病毒DNA、RNA和蛋白质正在这些细胞系中进行分析。
细胞因子如NFkB、NFAT、c-fos/jun、激酶、甲基酶和
细胞因子可能控制病毒的不同程度
将对这些不同的细胞系中发生的复制进行研究。
英文摘要
HIV-1 has been known to infect a variety of non lymphoid cell lines,
where the mode of entry has been postulated to involve an additional or
an independant receptor or a second messenger-like molecule. The extent
of viral replication in these cell lines is vastly different from
productive to abortive infections suggestive of host dependant controls
on viral replication. These model systems are ideal for identification
of cellular and viral factors involved in relication. Also, in some
instances, certain epithelial cells from patients ( e.g colon, cervical
etc) have been shown to harbor viral nucleic acid. Recent epidemiologic
studies suggest that some transmission to the fetus may occur in utero
and may involve infection of non lymphoid cell types. We have initiated
studies to explore mechanisms of active or possibly abortive viral
infections in these cell types. The target cells we have chosen to work
with are neuroblastoma cell lines SKNSH, SKNMC, a human embryonic cell
line, L132, two cervical cell lines SiHa and C33A, two uterine cell
lines HS 825T and HS 258T and a vaginal cell line HS 769 Vg. These cell
lines have been infected with HIV-1 and the course of infection is being
monitored. The kinetics of viral replication assessed by synthesis of
viral DNA, RNA and proteins is being analyzed in these cell lines.
Cellular factors such as NFkB, NFAT, c-fos/jun, kinases, methylases and
cytokines that may govern the different extents to which viral
replication occurs in these different cell lines will be investigated.
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会议论文
VIRUS-CELL INTERACTIONS AND HOST FACTORS IN HIV PATHOGENESIS
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批准号:5200814
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:I K HEWLETT
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依托单位:
CELLULAR PATHWAYS INVOLVED IN VIRAL INDUCTION--THEIR ROLE IN HIV PATHOGENESIS
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批准号:3770409
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:I K HEWLETT
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依托单位:
EFFICACY OF PASSIVE IMMUNOTHERAPY IN AIDS ASSESSED BY PCR
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批准号:3804851
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:I K HEWLETT
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依托单位:
IMMUNIZATION WITH HIV IMMUNE GLOBULIN IN THE PREVENTION OF HIV INFECTION IN PAN
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批准号:3804852
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:I K HEWLETT
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依托单位:
VIRAL DETERMINANTS OF HIV-1 PATHOGENESIS BY CONSTRUCTION OF RECOMBINANT VIRUSES
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批准号:3804854
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:I K HEWLETT
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依托单位:
RAPID AND QUANTITATIVE DETECTION BY PCR OF HIV-1 SPECIFIC DNA AND RNA
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批准号:3792569
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:I K HEWLETT
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依托单位:
DETECTION OF MULTIPLE VIRUSES BY PCR
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批准号:3792438
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:I K HEWLETT
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依托单位:
EFFICACY OF HYPERIMMUNE PLASMA IN AIDS
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批准号:3792575
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:I K HEWLETT
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依托单位:
VIRAL ETIOLOGY OF AIDS ASSOCICATED KAPOSI'S SARCOMA IN HIV NEGATIVE INDIVIDUALS
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批准号:3792605
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:I K HEWLETT
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依托单位:
NUCLEIC ACID BASED DETECTION AND QUANTITATION OF HIV-1 AND HIV-2
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批准号:3748264
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:I K HEWLETT
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依托单位:
INHIBITION OF HIV-1 AND HIV-2 WITH ANTISENSE OLIGONUCLEOTIDES AND RIBOZYMES
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批准号:3792576
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:I K HEWLETT
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依托单位:
INFECTION OF NON-HEMATOPOIETIC CELLS WITH HIV-1 AND HIV-2
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批准号:3804840
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:I K HEWLETT
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依托单位:
DETECTION OF MULTIPLE VIRUSES BY PCR CO-AMPLIFICATION
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批准号:3804838
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:I K HEWLETT
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依托单位:
INDUCTION OF HIV-1 FROM LATENTLY INFECTED CELL LINES BY CHEMICAL CARCINOGENS
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批准号:3804841
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:I K HEWLETT
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依托单位:
ASSESSMENT OF HIV INFECTION IN SPANISH SERONEGATIVE IVDAS AND THEIR PARTNERS
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批准号:3811156
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:I K HEWLETT
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依托单位:
INFECTION OF NON-HEMATOPOIETIC CELLS WITH HIV-1 AND HIV-2
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批准号:3811160
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:I K HEWLETT
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依托单位:
CELLULAR PATHWAYS INVOLVED IN VIRAL INDUCTION--THEIR ROLE IN HIV PATHOGENESIS
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批准号:3748262
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:I K HEWLETT
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依托单位:
ANTI-HIV ACTIVITY OF ANTINEOPLASTONS
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批准号:3792594
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:I K HEWLETT
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依托单位:
DETECTION OF HIV BY A MAGNETIC BEAD BASED VIRAL CAPTURE ASSAY
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批准号:3792599
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:I K HEWLETT
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依托单位:
CELLULAR FACTORS THAT CONTROL VIRAL EXPRESSION AND REGULATION
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批准号:3792574
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:I K HEWLETT
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依托单位:
海外基金