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IMMUNIZATION WITH HIV IMMUNE GLOBULIN IN THE PREVENTION OF HIV INFECTION IN PAN

IMMUNIZATION WITH HIV IMMUNE GLOBULIN IN THE PREVENTION OF HIV INFECTION IN PAN
HIV 免疫球蛋白免疫预防潘县 HIV 感染
批准号：
3804852
负责人：
I K HEWLETT
金额：
$0.0万
依托单位：
CENTER BIOLOGICS EVALUATION RESEARCH TRANSFUSION
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/3804852
关键词：
AIDS vaccines HIV infections Pan active immunization antibody neutralization test enzyme linked immunosorbent assay globulins human immunodeficiency virus polymerase chain reaction tissue /cell culture

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中文摘要
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英文摘要
The use of an HIV immuneglobulin (HIVIG) in the prevention of infection in chimpanzees was investigated. In previous experiments, no protection was observed when relatively high challenge doses were used. In the present study, HIVIG protected against a challenge dose (10 CID50) ten-fold lower than that used previously. The protected animal remained free of HIV infection as determined by co-culture and by PCR, and did not mount a primary immune response detectable by ELISA and neutralization assays.
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VIRUS-CELL INTERACTIONS AND HOST FACTORS IN HIV PATHOGENESIS
CELLULAR PATHWAYS INVOLVED IN VIRAL INDUCTION--THEIR ROLE IN HIV PATHOGENESIS
RAPID AND QUANTITATIVE DETECTION BY PCR OF HIV-1 SPECIFIC DNA AND RNA
DETECTION OF MULTIPLE VIRUSES BY PCR
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