IMMUNIZATION WITH HIV IMMUNE GLOBULIN IN THE PREVENTION OF HIV INFECTION IN PAN

HIV 免疫球蛋白免疫预防潘县 HIV 感染

• 批准号: 3804852
• 负责人: I K HEWLETT
• 金额: --
• 依托单位: CENTER BIOLOGICS EVALUATION RESEARCH TRANSFUSION
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3804852
• 关键词: AIDS vaccines; HIV infections; Pan; active immunization; antibody neutralization test; enzyme linked immunosorbent assay; globulins; human immunodeficiency virus; polymerase chain reaction; tissue /cell culture

The use of an HIV immuneglobulin (HIVIG) in the prevention of infection in chimpanzees was investigated. In previous experiments, no protection was observed when relatively high challenge doses were used. In the present study, HIVIG protected against a challenge dose (10 CID50) ten-fold lower than that used previously. The protected animal remained free of HIV infection as determined by co-culture and by PCR, and did not mount a primary immune response detectable by ELISA and neutralization assays.

HIV免疫球蛋白（HIVIG）在预防感染中的用途 黑猩猩进行了调查。 在以前的实验中， 当使用相对较高的激发剂量时观察到。 本 研究中，HIVIG对攻击剂量（10 CID50）的保护作用降低了10倍 比以前使用的。 受保护的动物仍然没有艾滋病毒 通过共培养和PCR确定的感染，并且没有增加 可通过ELISA和中和试验检测的初次免疫应答。