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EFFICACY OF HYPERIMMUNE PLASMA IN AIDS

EFFICACY OF HYPERIMMUNE PLASMA IN AIDS
超免疫血浆治疗艾滋病的功效
批准号：
3792575
负责人：
I K HEWLETT
金额：
$0.0万
依托单位：
CENTER BIOLOGICS EVALUATION RESEARCH TRANSFUSION
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/3792575
关键词：
AIDS AIDS therapy antiviral antibody human immunodeficiency virus 1 human subject neutralizing antibody passive immunization polymerase chain reaction virus DNA virus RNA virus antigen

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中文摘要
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英文摘要
Hyperimmune plasma was collected from healthy, HIV-1 infected individuals with high titers of neutralizing antibodies and administered to 50 AIDS patients. All patients were monitored for viral antibodies, antigen and viral nucleic acid by PCR. Peripheral blood mononuclear cells (PBMCs) and sera were collected from these individuals and from a group of placebo treated individuals. Viral load is being quantitated by DNA and RNA PCR on the lymphocytes and RNA PCR on serum. Preliminary results suggest that although there may be protection based on the levels of serum p24 antigen, viral DNA levels were not decreased.
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会议论文
VIRUS-CELL INTERACTIONS AND HOST FACTORS IN HIV PATHOGENESIS
CELLULAR PATHWAYS INVOLVED IN VIRAL INDUCTION--THEIR ROLE IN HIV PATHOGENESIS
EFFICACY OF PASSIVE IMMUNOTHERAPY IN AIDS ASSESSED BY PCR
IMMUNIZATION WITH HIV IMMUNE GLOBULIN IN THE PREVENTION OF HIV INFECTION IN PAN
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