EFFICACY OF HYPERIMMUNE PLASMA IN AIDS

超免疫血浆治疗艾滋病的功效

• 批准号: 3792575
• 负责人: I K HEWLETT
• 金额: --
• 依托单位: CENTER BIOLOGICS EVALUATION RESEARCH TRANSFUSION
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3792575
• 关键词: AIDS; AIDS therapy; antiviral antibody; human immunodeficiency virus 1; human subject; neutralizing antibody; passive immunization; polymerase chain reaction; virus DNA; virus RNA; virus antigen

Hyperimmune plasma was collected from healthy, HIV-1 infected individuals with high titers of neutralizing antibodies and administered to 50 AIDS patients. All patients were monitored for viral antibodies, antigen and viral nucleic acid by PCR. Peripheral blood mononuclear cells (PBMCs) and sera were collected from these individuals and from a group of placebo treated individuals. Viral load is being quantitated by DNA and RNA PCR on the lymphocytes and RNA PCR on serum. Preliminary results suggest that although there may be protection based on the levels of serum p24 antigen, viral DNA levels were not decreased.

从健康的HIV-1感染者中收集高免疫血浆， 具有高滴度中和抗体的个体， 50名艾滋病患者。 所有患者均接受病毒抗体监测， 抗原和病毒核酸。 外周血单个核 细胞（PBMC）和血清收集自这些个体和 安慰剂治疗组。 正在对病毒载量进行定量 通过淋巴细胞的DNA和RNA PCR以及血清的RNA PCR。初步 结果表明，虽然可能有保护基于 血清p24抗原水平、病毒DNA水平均未下降。