IMMUNOLOGIC STUDIES ON SCHISTOSOMIASIS

血吸虫病的免疫学研究

• 批准号: 3803123
• 负责人: A SHER
• 金额: --
• 依托单位: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3803123
• 关键词: Schistosoma japonicum; Schistosoma mansoni; cytokine; fibrosis; granuloma; helminthic antigen; helper T lymphocyte; immunopathology; immunotherapy; interleukin 2; interleukin 4; interleukin 5; laboratory mouse; macrophage; microorganism immunology; parasitic disease chemotherapy; schistosomiasis; vaccines

The aim of this project is to study mechanisms of immunity, immunoregulation, immune evasion and immunopathology in schistosomiasis with the ultimate goals of developing an experimental vaccine suitable for human trials as well as understanding the pathogenesis of disease. In work completed this year, mice infected with S. mansoni were demonstrated to have a selective defect in their capacity to mount Th1 cytokine responses to a foreign antigen. Moreover, IL-10 a cytokine previously shown to be produced by these animals, was demonstrated to inhibit the capacity of activated macrophages to kill schistosome larvae. Studies on immunopathogenesis revealed that IL-2 depletion reduces both granuloma formation and fibrosis in S. mansoni infected mice while downregulating IL-5 but up-regulating IL-4 synthesis. The pattern of cytokine production in S. japonicum infected mice was found to closely mirror that previously observed in S. mansoni infected animals.

这个项目的目的是研究免疫机制，