课题基金 / 基金详情

DEVELOPMENTAL ADAPTATIONS OF TRYPANOSOMA CRUZI TO THE VERTEBRATE IMMUNE SYSTEM

DEVELOPMENTAL ADAPTATIONS OF TRYPANOSOMA CRUZI TO THE VERTEBRATE IMMUNE SYSTEM
克氏锥虫对脊椎动物免疫系统的发育适应
批准号：
3809583
负责人：
A SHER
金额：
$0.0万
依托单位：
NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/3809583
关键词：
Trypanosoma cruzi complement pathway complementary DNA cyclic AMP developmental genetics host organism interaction life cycle microorganism immunology nucleic acid sequence protozoal antigen trypanosomiasis

项目摘要

项目成果

A SHER的其他基金

相似基金

相关文献

中文摘要
翻译
点击翻译按钮获取中文摘要
英文摘要
In this project we have been studying developmental adaptations of T. cruzi to the vertebrate host and, in particular, the molecular basis of adaptive changes occurring during the differentiation of epimastigotes (vector stare) to metacyclic tryptomastigotes (infective stage). This year we succeeded in cloning a previously characterized developmentally regulated molecule from the parasite which has decay accelerating factor (DAF) activity inhibiting parasite mediated complement activation. The molecule has extensive sequence homology with human DAF.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
DEVELOPMENTAL ADAPTATIONS OF TRYPANOSOMA CRUZI TO THE VERTEBRATE IMMUNE SYSTEM
IMMUNE REGULATION IN TOXOPLASMOSIS AND OTHER OPPORTUNISTIC INFECTIONS
IMMUNOLOGIC STUDIES ON SCHISTOSOMIASIS
IMMUNOLOGIC STUDIES ON SCHISTOSOMIASIS
海外基金