DEVELOPMENTAL ADAPTATIONS OF TRYPANOSOMA CRUZI TO THE VERTEBRATE IMMUNE SYSTEM
DEVELOPMENTAL ADAPTATIONS OF TRYPANOSOMA CRUZI TO THE VERTEBRATE IMMUNE SYSTEM
批准号:
3818149
负责人:
A SHER
金额:
$0.0万
依托单位国家:
美国
项目类别:
财政年份:
--
资助国家:
美国
项目状态:
未结题
起止时间:
至
关键词:
Trypanosoma cruzi affinity chromatography complement complement receptor complementary DNA developmental genetics gene expression genetic translation host organism interaction immunogenetics intracellular parasitism laboratory mouse lectin macrophage membrane proteins microorganism culture microorganism immunology molecular cloning protooncogene protozoal antigen surface antigens tissue /cell culture trypanosomiasis
中文摘要
在这个项目中,我们一直在研究
T. cruzi对脊椎动物宿主的作用,特别是
在分化过程中发生适应性变化的基础
上鞭毛体(媒介阶段)到后环锥鞭毛体
(感染期)。
A. 细胞内存活发育调控的研究
巨噬
CR 3显示外鞭毛体进入小鼠巨噬细胞
受体,而进入和生存的元环
锥虫鞭毛体被证明是增强补体,但也
依赖于纤维连接蛋白受体。
B。 后循环形式中阶段特异性基因表达的分析
从T. cruzi和L.
少校 序列分析表明,T. cruzi
克隆与c-fos原癌基因同源,而L.主要
克隆与RNA聚合酶β链具有同源性。
英文摘要
In this project we have been studying developmental adaptations of
T. cruzi to the vertebrate host and, in particular the molecular
basis of adaptive changes occurring during the differentiation of
epimastigotes (vector stage) to metacyclic trypomastigotes
(infective stage).
A. Studies on developmental control of intracellular survival in
macrophages
Epimastigotes were shown to enter mouse macrophages by CR3
receptors while the entry and survival of metacyclic
trypomastigotes was shown to be enhanced by complement but also to
depend on fibronectin receptors.
B. Analysis of stage-specific gene expression in metacyclic forms
Metacyclic stage specific cDNA's were cloned from T. cruzi and L.
major. Sequence analysis indicated that the principal T. cruzi
clone has homology with a c-fos proto-oncogene while the L. major
clone has homology with beta-chain of RNA polymerase.
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DEVELOPMENTAL ADAPTATIONS OF TRYPANOSOMA CRUZI TO THE VERTEBRATE IMMUNE SYSTEM
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批准号:4688413
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:A SHER
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依托单位:
DEVELOPMENTAL ADAPTATIONS OF TRYPANOSOMA CRUZI TO THE VERTEBRATE IMMUNE SYSTEM
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批准号:3809583
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:A SHER
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依托单位:
IMMUNE REGULATION IN TOXOPLASMOSIS AND OTHER OPPORTUNISTIC INFECTIONS
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批准号:5200514
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:A SHER
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依托单位:
IMMUNOLOGIC STUDIES ON SCHISTOSOMIASIS
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批准号:3803123
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:A SHER
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依托单位:
IMMUNOLOGIC STUDIES ON SCHISTOSOMIASIS
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批准号:3822010
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:A SHER
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依托单位:
IMMUNE REGULATION IN TOXOPLASMOSIS AND OTHER OPPORTUNISTIC INFECTIONS
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批准号:6160649
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:A SHER
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依托单位:
IMMUNE REGULATION IN TOXOPLASMOSIS AND OTHER OPPORTUNISTIC INFECTIONS
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批准号:3746588
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项目类别:
-
资助金额:$0.0万
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财政年份:--
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负责人:A SHER
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依托单位:
IMMUNOLOGIC STUDIES ON SCHISTOSOMIASIS
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批准号:3818153
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:A SHER
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依托单位:
MOLECULAR STUDIES OF THE GENOME AND SURFACE OF SCHISTOSOMA MANSONI
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批准号:4688414
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:A SHER
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依托单位:
IMMUNOLOGIC STUDIES ON SCHISTOSOMIASIS
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批准号:2566727
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:A SHER
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依托单位:
IMMUNOLOGIC STUDIES ON SCHISTOSOMIASIS
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批准号:6160569
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:A SHER
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依托单位:
IMMUNOLOGIC STUDIES ON SCHISTOSOMIASIS
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批准号:3809587
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项目类别:
-
资助金额:$0.0万
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财政年份:--
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负责人:A SHER
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依托单位:
IMMUNOLOGIC STUDIES ON SCHISTOSOMIASIS
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批准号:3768758
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:A SHER
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依托单位:
IMMUNOLOGIC STUDIES ON SCHISTOSOMIASIS
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批准号:3790697
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:A SHER
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依托单位:
IMMUNOLOGIC STUDIES ON SCHISTOSOMIASIS
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批准号:3960501
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:A SHER
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依托单位:
IMMUNOLOGIC STUDIES ON SCHISTOSOMIASIS
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批准号:3746488
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项目类别:
-
资助金额:$0.0万
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财政年份:--
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负责人:A SHER
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依托单位:
MOLECULAR STUDIES OF THE GENOME AND SURFACE OF SCHISTOSOMA MANSONI
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批准号:3818150
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:A SHER
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依托单位:
STUDIES ON IMMUNE REGULATION IN TOXOPLASMOSIS
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批准号:3803260
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:A SHER
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依托单位:
MOLECULAR STUDIES OF THE GENOME AND SURFACE OF SCHISTOSOMA MANSONI
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批准号:3960497
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:A SHER
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依托单位:
IMMUNE REGULATION IN TOXOPLASMOSIS AND OTHER OPPORTUNISTIC INFECTIONS
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批准号:2566813
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:A SHER
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依托单位:
海外基金