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IMMUNOLOGIC STUDIES ON SCHISTOSOMIASIS

IMMUNOLOGIC STUDIES ON SCHISTOSOMIASIS
血吸虫病的免疫学研究
批准号：
3809587
负责人：
A SHER
金额：
$0.0万
依托单位：
NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/3809587
关键词：
Schistosoma T lymphocyte anthelmintics eosinophilia fibrosis granuloma helminthic antigen human tissue immunological substance immunology immunopathology immunotherapy interferons interleukin 2 interleukin 5 laboratory mouse microorganism immunology monoclonal antibody parasitic disease chemotherapy schistosomiasis vaccines

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中文摘要
翻译
这个项目的目的是研究免疫、免疫逃避的机制。 和血吸虫病的免疫病理学，最终目标是 开发一种适用于人体试验的实验性疫苗以及 了解疾病的发病机制。 在今年完成的工作中，血吸虫卵被证明是主要的 在感染小鼠中观察到的Th2反应的刺激。此外，鸡蛋 以及产卵被证明下调Th1细胞因子(干扰素-伽马， 和IL-2)在免疫小鼠和专利前期小鼠中的产生 感染。白介素10(CSIF)是一种新发现的细胞因子。 由感染小鼠产生的T细胞及其活性可能解释了 Th1细胞因子合成下调。
英文摘要
The aim of this project is to study mechanisms of immunity, immune evasion and immunopathology in schistosomiasis with the ultimate goals of developing an experimental vaccine suitable for human trials as well as understanding the pathogenesis of disease. In work completed this year, the schistosome egg was shown to be the major stimulus of the Th2 response observed in infected mice. In addition, eggs as well as oviposition were shown to down regulate Th1 cytokine (IFN-gamma, and IL-2) production in vaccinated mice as well as mice with prepatent infections. IL-10 (CSIF) a newly discovered cytokine was found to be produced by T cells from infected mice and its activity may explain the observed down-regulation in Th1 cytokine synthesis.
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会议论文
DEVELOPMENTAL ADAPTATIONS OF TRYPANOSOMA CRUZI TO THE VERTEBRATE IMMUNE SYSTEM
IMMUNE REGULATION IN TOXOPLASMOSIS AND OTHER OPPORTUNISTIC INFECTIONS
DEVELOPMENTAL ADAPTATIONS OF TRYPANOSOMA CRUZI TO THE VERTEBRATE IMMUNE SYSTEM
IMMUNE REGULATION IN TOXOPLASMOSIS AND OTHER OPPORTUNISTIC INFECTIONS
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