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CARDIAC MORPHOLOGY AND FUNCTIONAL CHANGES INDUCED BY EPIRUBICIN

CARDIAC MORPHOLOGY AND FUNCTIONAL CHANGES INDUCED BY EPIRUBICIN
表柔比星引起的心脏形态和功能变化
批准号：
3879023
负责人：
V J FERRANS
金额：
$0.0万
依托单位：
NATIONAL HEART, LUNG, AND BLOOD INSTITUTE
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/3879023
关键词：
biopsy dosage doxorubicin drug adverse effect endocardium heart function histology human tissue pathology

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中文摘要
翻译
进行心功能研究，心内膜心肌活组织检查 在24名接受表阿霉素总累积剂量的患者中获得 肿瘤治疗剂量为180 mg/m(2)~918 mg/m(2)。一个 共有20例活组织检查可评价。组织学和超微结构改变 与其他蒽环类药物引起的相似。一个坚强的人 表柔比星总剂量与 病理改变用Billingham评分进行量化(r=0.7，p= 0.0006)。有望接受超过450种表柔比星治疗的患者 Mg/m(2)应以监测结果为准。
英文摘要
Cardiac functional studies were made and endomyocardial biopsies were obtained on 24 patients who received epirubicin in total cumulative doses arranging from 180 mg/m(2) to 918 mg/m(2) for the treatment of neoplasm. A total of 20 biopsies were evaluable. Histologic and ultrastructural changes were similar to those caused by other anthracycline agents. A strong correlation was demonstrated between total dose of epirubicin and pathologic change as quantified using the Billingham scale (r = 0.7, p = 0.0006). Patients who are expected to receive epirubicin in excess of 450 mg/m(2) should be based on the results of monitoring.
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会议论文
STUDIES OF THE MORPHOLOGY OF THE BIOPROSTHETIC HEART VALVES
SURGICAL PATHOLOGY OF THE CARDIOVASCULAR SYSTEM
ULTRASTRUCTURE AND FUNCTION OF THE MYOCARDIUM--AN OVERVIEW
INTRALUMINAL FIBROSIS IN FIBROTIC LUNG DISORDERS
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